内源性促红细胞生成素与慢性心力衰竭

Endogenous erythropoietin and chronic heart failure

贫血常见于慢性心力衰竭(CHF)患者,其与CHF患者症状和心功能恶化以及死亡率增加有相关性。CHF患者内源性促红细胞生成素(EPO)水平上调,并与CHF严重程度相关。研究发现,EPO水平是CHF患者死亡和因心力衰竭再住院的强预测指标,并独立于血红蛋白水平以及其它已经确定的CHF严重程度的标志物。与非CHF患者相比,CHF患者EPO与血红蛋白水平仅呈弱相关性。

Anemia is common and is associated with worse symptoms, greater impairment in functional capacity and a significant increase in mortality in patients with chronic heart failure （CHF）. Endogenous erythropoietin （EPO） levels are higher in CHF patients and correlate with the severity of CHF. The levels of EPO are found to be a strong predictor of mortality and CHF hospitalization independent of hemoglobin levels and other established markers of CHF severity. Furthermore, in CHF patients, a poor correlation is observed between EPO and hemoglobin levels, in contrast with the non-CHF patients.