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人高迁移率族蛋白B1在风湿免疫性疾病中的研究进展 被引量：3

The research advances of high mobility group box 1 protein in autoimmune rheumatic diseases
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摘要 人高迁移率族蛋白B1(HMGB1)是细胞核内典型的非组蛋白。HMGB1在细胞和组织中分布十分广泛,受到炎症刺激后能从坏死或损伤细胞被动释放,并可诱导树突状细胞上调其成熟的表面抗原。本文详细介绍了HMGB1的结构、功能特点及HMGB1在系统性红斑狼疮、类风湿关节炎、肌炎、系统性硬化症、干燥综合征等风湿免疫性疾病中的表达情况。随着对HMGB1研究的不断深入,HMGB1在风湿性疾病诊断、治疗等中的潜力将进一步得到发展。 High mobility group box 1 protein（ HMGB1 ） is originally identified as a DNA-binding protein that functions as a structural co-factor. HMGB1 as a potent, proinflammatory cytokine, is released passively by damaged or necrotic cells. Released HMGB1 acts as a mediator of macrophage activation and induces secretion of proinflammatory cytokines. In this article, we briefly reviewed its role in system lupus erythematosus, rheumatoid arthritis, polymyositis and dermatomyositis, systemic sclerosis, primary sjgren＇s syndrome. With the in-depth research of HMGB1, the potential application of HMGB1 in rheumatic diseases＇ diagnosis and treatment will get further development.
作者 颜雪梅 游运辉
机构地区 中南大学湘雅医院风湿免疫内科
出处 《国际内科学杂志》 CAS 2008年第4期241-244,共4页 International Journal of Internal Medicine
关键词 人高迁移率族蛋白B1 风湿免疫性疾病 High mobility group box 1 protein Rheumatic diseases
分类号 R593 [医药卫生—内科学]
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参考文献20

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同被引文献42

  • 1熊毅,陈明,张继来,田少江.风湿免疫性疾病患者血清骨桥蛋白的检测及意义[J].郧阳医学院学报,2010,29(4):358-359. 被引量：1
  • 2章群,叶冬青.系统性红斑狼疮合并妊娠患者自身抗体水平变化与妊娠结局[J].中华妇产科杂志,2007,42(1):68-70. 被引量：7
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  • 6Muller S,Ronfani L,Bianchi ME.Regulated expression and subcelluar localization of HMGB 1 .a chrom at in protein with cytokine function [J].J Intern Med,2004,255(3):323-343.
  • 7Li J,Kokkola R,Tabibzadeh S,et al.Structural basis for the proinflammatory cytokine activity of high mobility group boxl [J].MolMed,2003 9(1-2k37-45.
  • 8Palumbo R,Galvez BG,Pusteria T,et al.Cells migrating to sites of tissue damage in response to the danger signal HMGB1 require NF- kappaB a ctivation[J].J Cell Biol,2007,179(1):33-40.
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  • 10Andersson U,Erlandsson-Harris H,Yang H,et al.HMGB1 as a DNA- binding cytokine[J] .J Leukoc Biol,2002,72 (6): 1084-1091.

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国际内科学杂志
2008年 第4期

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