先驱体裂解HA/CaSiO_3多孔材料及性能

Preparation and Properties of Hydroxyapatite/Wollastonite Composite Scaffolds by PP Method

采用先驱体裂解法以聚碳硅烷(PCS)和碳酸钙(CaCO_3)作为硅灰石(CaSiO_3)的前驱体于1200℃常压烧结制备了羟基磷灰石/硅灰石多孔支架材料。采用XRD对材料进行物相分析;SEM进行材料内部组织结构的观察;万能试验机测其压缩强度;阿基米得法测其气孔率;模拟体液试验评估其生物活性。结果表明:制备的材料主晶相为羟基磷灰石和硅灰石,气孔率介于70%～80%之间,当硅灰石质量分数为30%时,支架的压缩强度达到3.48 MPa,气孔率为78.2%,且材料具有良好的生物活性。研究表明了先驱体裂解法制备HA/CaSiO_3细胞支架的可行性。

Porous hydroxyapatite/wollastonite composite scaffold was obtained by precursor pyrolysis（PP） at 1200 ℃. The phase components and morphology of the materials were characterized by X-ray diffraction（XRD） and scanning electron microscopy（SEM）. Porosity was measured by Archimedean method, and the compressive strength was also measured. The simulated body fluids （SBF） experiments were conducted to evaluate bioactivity. Hydroxyapatite and wollastonite were the main phases after sintering at 1200 ℃. The porosity of the composite scaffolds reached 70%～80%. The pore diameters of macroporous HA/WS scaffolds ranged from 100μm to 300 /am, a structure favorable for the bone tissue in-growth. The compressive strength was 3.48 MPa which was higher than the pure porous HA matrix. In the SBF tests, a layer of randomly oriented apatite crystals formed on the scaffold surface after immersing the samples in SBF. This suggested the good bioactivity of the composite material and the feasibility for tissue engineering.