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LC-NMR-MS联用技术及其在代谢物结构研究中的应用 被引量:6

Online hyphenation of LC-NMR-MS and its application in metabolites identification
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摘要 本文综述了液相色谱-核磁共振-质谱(LC-NMR-MS)联用技术的最新发展,讨论了该技术在应用中面临的主要问题和解决方法,评述了 LC-NMR-MS 的联机方式和工作模式,并介绍了 LC-NMR-MS 技术在药物代谢物结构方面应用现状,最后展望了其今后的发展方向。 This paper introduce the development of liquid chromatography -nuclear magnetic resonance-mass spectrometry (LC -NMR- MS) technology and discuss the problems and resolvents encountered in application, then comment on the instrumental configurations and primary working modes of LC - NMR - MS. Application of LC - NMR - MS in characterization of metabolites in biological specimen were reviewed. Finally the fusthe development of LC - NMR - MS technology is predicted.
出处 《药物分析杂志》 CAS CSCD 北大核心 2008年第4期637-641,共5页 Chinese Journal of Pharmaceutical Analysis
基金 国家自然科学基金资助项目(No.20672143 30271608)
关键词 液相色谱-核磁共振-质谱 代谢物 综述 liquid chromatography - Nuclear magnetic resonance - Mass spectrometry metabolites review
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