摘要
本文综述了液相色谱-核磁共振-质谱(LC-NMR-MS)联用技术的最新发展,讨论了该技术在应用中面临的主要问题和解决方法,评述了 LC-NMR-MS 的联机方式和工作模式,并介绍了 LC-NMR-MS 技术在药物代谢物结构方面应用现状,最后展望了其今后的发展方向。
This paper introduce the development of liquid chromatography -nuclear magnetic resonance-mass spectrometry (LC -NMR- MS) technology and discuss the problems and resolvents encountered in application, then comment on the instrumental configurations and primary working modes of LC - NMR - MS. Application of LC - NMR - MS in characterization of metabolites in biological specimen were reviewed. Finally the fusthe development of LC - NMR - MS technology is predicted.
出处
《药物分析杂志》
CAS
CSCD
北大核心
2008年第4期637-641,共5页
Chinese Journal of Pharmaceutical Analysis
基金
国家自然科学基金资助项目(No.20672143
30271608)
关键词
液相色谱-核磁共振-质谱
代谢物
综述
liquid chromatography - Nuclear magnetic resonance - Mass spectrometry
metabolites
review