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腺苷A2A受体与帕金森病治疗关系的研究进展 被引量：1

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摘要 帕金森病（PD）是一种以中脑黑质致密部多巴胺神经元变性、缺失为主要的病理改变，以静止性震颤、运动迟缓、肌强直和姿势步态异常为主要临床表现的神经系统变性疾病。PD的治疗仍以左旋多巴替代疗法为主，但长期使用多巴胺类药物可引起运动波动、异动症等运动并发症。目前，治疗PD的药物只能缓解症状，不能从根本上阻止多巴胺能神经元的变性、死亡。近年来，腺苷A2A受体拮抗剂倍受关注，有望成为治疗PD的新型药物。现就腺苷A2A受体的分布特点及腺苷A2A受体拈抗剂与PD治疗关系的研究进展作一综述。
作者 宋璐 刘振国
机构地区 上海交通大学医学院附属新华医院神经内科
出处 《中华老年医学杂志》 CAS CSCD 北大核心 2008年第4期313-316,共4页 Chinese Journal of Geriatrics
基金 教育部留学回国人员科研启动基金 上海市教育委员会基金（06BZ048）
关键词 腺苷A2A受体拮抗剂 PD治疗 帕金森病 多巴胺能神经元 神经系统变性疾病 神经元变性 胺类药物 黑质致密部
分类号 R686 [医药卫生—骨科学]
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参考文献22

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同被引文献58

  • 1杨梅,孙圣刚.镁对帕金森病大鼠黑质多巴胺神经元的影响[J].临床神经病学杂志,2008,21(6):437-440. 被引量：7
  • 2张静文.帕金森病防治的新靶点[N].中囯医学论坛报,2010-07-22(A2).
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  • 6Lew MF, Pahwa R, Leahey M, et al. Safety and efficacy of newly formulated selegiline orally disintegrating tablets as an adjunct to levodopa in the management of ‘off’ episodes in patients with par- kinsonn's disease [ J ]. Curr Med Res Opin, 2007,23 ( 4 ) : 741 - 750.
  • 7Luszczki JJ. Third-generation antiepileptic drugs : mechanisms of action, pharmacokinetics and interactions [ J ]. Pharmacol Rep, 2009,61 (2) :197-216.
  • 8Shah U, Hodgson R. Recent progress in the discovery of adenosine A(2A) receptor antagonists for the treatment of parkinson's dis- ease [ J ]. Curr Opin Drug Discov Deve1,2010,13 (4) :466-480.
  • 9Jenner P, Mori A, Hauser R, et al. Adenosine, adenosineA2A an- tagonists and parkinsonn's disease [ J ]. Parkinsonism Relat Dis- ord ,2009,15 ( 3 ) :406-413.
  • 10Elisabena T, Nieola S, Franeo B, et al. Characterization of the an- tiparkinsonian effects of the new adenosine A2A receptor antago- nist ST1535 :acute and subchrouic smdiesln rats[ J ]. Eur J Phar- maco1,2007,566 ( 1-3 ) :94-102.

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中华老年医学杂志
2008年 第4期

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