摘要
目的:观察铁叶绿酸钠改善大鼠记忆作用及对大鼠脑血氧的影响。方法:用铁叶绿酸钠25,50,100mg.kg-1分别给大鼠连续灌胃给药,进行迷宫试验,对东茛菪碱损伤记忆拮抗作用试验及其对脑血氧的影响试验。结果:铁叶绿酸钠可以减少大鼠达标前所需的反应次数、提高大鼠主动回避反应率、缓解东茛菪碱所致的学习障碍;增加大鼠血氧分压、提高大鼠血氧浓度和血氧饱和度。结论:铁叶绿酸钠具有改善记忆的作用。
OBJECTIVE To observe the effect of sodium ferrous chlorophyll on improving memory and cerebrum blood oxygen of rats. METHODS Maze test, contradictive action against scopolamine induced memory damnification and the influence on cerebrum blood oxygen were tested after irrigating 25,50, 100 mg·kg^-1 of sodium ferrous chlorophyll to rats. RESULTS Sodium ferrous chlorophill could decrease action frequency before reaching the mark, increase the ability of initiative avoiding, mitigate the study impediment induced by scopolamine, increase cerebrum blood oxygen content. CONCLUSION Sodium ferrous chlorophyll has the effect of improving memory.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2008年第8期620-622,共3页
Chinese Journal of Hospital Pharmacy
关键词
铁叶绿酸钠
改善记忆
东莨菪碱
sodium ferrous chlorophyll
memory improvement
scopolamine
