短期甘精胰岛素联合阿卡波糖门诊治疗初诊2型糖尿病的疗效观察

Effect of short-term treatment of insulin glargine combined with acarbose on newly diagnosed type 2 diabetes mellitus

目的:观察短期甘精胰岛素联合阿卡波糖门诊治疗初诊2型糖尿病的疗效及安全性。方法:收集2007年7-9月我院糖尿病专科门诊患者中初次诊断的2型糖尿病且空腹血糖≥13.9mmol/L患者共47例,予甘精胰岛素联合阿卡波糖治疗,经过8～12周的治疗,比较治疗前、后空腹血糖(FBG)、餐后2h血糖(PBG)、糖化血红蛋白(HbA1c)的差异,同时观察总胆固醇(CHOL)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、血常规、肝肾功能的变化及药物副作用。结果:治疗8～12周后所有患者血糖及HbA1c均下降明显,副作用主要以胃肠道反应为主,占12.76%,期间无一例出现低血糖反应。随诊2周后,45例患者FBG及PBG仍控制良好。结论:甘精胰岛素联合阿卡波糖门诊治疗初诊2型糖尿病患者,短期内能使血糖下降理想,且安全,副作用轻微。

Objective To observe the effect and safety of insulin glargine combined with acarbose on patients with newly diagnosed type 2 diabetes mellitus （T2DM）. Methods Forty-seven newly diagnosed T2DM patients （fasting blood glucose ≥ 13.9 mmol/L） were treated with insulin glargine and acarbose. Compare the differences of FBG,2 h PG,HbAlc before and afte 8～12 weeks treatment. At the same time,observe the changes of CHOL,TG,LDL-C,blood routine test,liver and kidney function,and side effects. Results After eight to twelve weeks＇ treatment,the levels of blood glucose, glycosylated hemoglobin and blood lipid were reduced significantly. Side effects including gastrointestinal tract reaction were rare,and there were no hypoglycemia. Follow-up for two weeks,forty-five diabetics were still under well blood glucose control.Conclusion Insulin glargine combined with acarbose can make blood glucose to descend ideally on newly diagnosed type 2 diabetes mellitus with hyperglycemia in short-term, and it is also safety and low side effect.