瑞香狼毒总木脂素的体外抗肿瘤活性

Antitumor activities in vitro of total-lignan from Stellera chamaejasme L.in vitro

研究了瑞香狼毒总木脂素的体外抗肿瘤作用.用MTT比色分析法、集落形成法对瑞香狼毒总木脂素的体外抗肿瘤活性进行研究,并与长春新碱的活性进行了比较.瑞香狼毒总木脂素成分对肿瘤细胞株SGC-7901,HEP-7402和HL-60的增殖及克隆形成具有较强的抑制作用,其体外抗肿瘤活性高于或接近于长春新碱,证明瑞香狼毒总木脂素成分具有较强的体外抗肿瘤作用.

The antitumor activities in vitro of total-lignan from Stellera chamaejasme were studied in this paper and the in vitro antitumor activities were determined by a MTT assay and clone formation against human cancer cell lines, such as stomach cancer SGC-7901, hepatocarcinoma HEP-7402 and leukemia HL-60. Total-lignan has significant inhibition of cell proliferation and clone formation of human cancer cell lines such aS SGC-7901 and BEL-7402, and its antitumor activities in vitro are higher than those of vincristine. Total-lignan from Stellera chamaejasme has a significant antitumor effect in vitro.