hTERT启动子的转录调控机制及其靶向性介导肿瘤治疗的研究进展

Transcriptional regulation mechanism and targeted cancer therapy of human telomerase reverse transcriptase promoter

端粒酶与肿瘤发生发展的关系是近年来肿瘤研究领域的热点之一。端粒酶是一种核糖核蛋白复合物,在绝大多数恶性肿瘤细胞中呈阳性表达,而在正常体细胞中则一般为阴性。端粒酶的活性表达主要是通过hTERT基因的转录机制严格调控的。端粒酶的活化与肿瘤的发生发展及细胞衰老和永生化关系密切。hTERT基因启动子为恶性肿瘤早期诊断、预后评估及基因治疗提供了新的思路。

Recently, the relationship between telomerase and cancer has become a heated issue in the field of cancer research. Telomerase is a ribonucleoprotein enzyme, which is positively expressed in most malignant tumor cells, while negatively expressed in normal somatic ones. And the transcriptional regulation of human telomerase reverse transcriptase （hTERT） promoter is the main mechanism for telomerase expression,which plays a significant role in the developmet of tumor as well as cell aging and immortalization, hTERT promoter has become a new target for the early diagnosis, prognostic evaluation and gene therapy of cancer.