IFNγ在动脉粥样硬化形成中的作用

Roles of IFNγ in the atherogenesis

干扰素γ(IFNγ)又称免疫干扰素,其抗病毒活性较低,免疫调节和抗细胞增殖作用较强,是一种强的巨噬细胞、NK细胞、血管内皮细胞活化剂。IFNγ增强抗原提呈,活化T淋巴细胞,与多种致炎因子相互作用,促进粥样病变处炎症反应,加重病变进展。作为脂质代谢相关酶的调节因子,IFNγ诱导泡沫细胞形成,并活化内皮细胞促进动脉粥样硬化。但也有研究显示,它可影响一些脂质受体抑制泡沫细胞形成,并减少平滑肌细胞增殖而对动脉粥样硬化形成起保护作用。

Interferonγ （IFNγ） , also called immune interferon, has low activity against virus, but it plays strong role in immunological regulation and in inhibition of cell proliferation. It is a strong activator for macrophages, NK cells and vascular endothelial cells. It can promote the inflammation of the atherosclerosis lesions through enhancing antigen-presentation, activating T lymphocytes and interacting with many kinds of cytokines. As a mediator of enzymes related to lipid metabolism, IFNγ can induce the formation of foam cells as well as activate endothelial cells, and thus accelerate atherogenesis. However, there is also evidence that IFNγ can inhibit the formation of foam cells by affecting lipid receptors and decreasing vascular smooth cells proliferation, suggestting that IFNγ may also has an anti-antherosclerosis effect.