伴家族史的2型糖尿病危险因素的病例对照研究

A Case Control Study on Risk Factors of Type 2 Diabetes With Family History

为探讨2型糖尿病代谢特征及发病的危险因素,选取大连地区91例有家族史的T2DM患者为病例组,以44例患者的配偶(糖耐量正常)为对照组,进行流行病学问卷调查和体格检查,同时测定空腹血糖、空腹胰岛素、总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白等指标,采用稳态模型法计算两组的胰岛素抵抗指数和β细胞功能指数,并进行多因素非条件Logistic回归分析。结果显示:TG、腰臀比和Ln(HOMAIR)病例组高于对照组,而Ln(HOMAβ)则病例组低于对照组,均具有统计学意义(P<0.05)。多因素非条件Logistic回归分析结果提示,影响T2DM发病的因素有心血管疾病史、Ln(HOMAIR)及Ln(HOMAβ)。由此可见T2DM患者存在血脂代谢异常;心血管疾病史和Ln(HOMAIR)为发病的危险因素,Ln(HOMAβ)为保护因素。

To investigate the metabolism character and risk factors of type 2 diabetes mellitus （T2DM）, we select 91 T2DM who had family history and 44 non- diabetic spouses as controls in Dalian. A questionnaire survey and medical examination were conducted. The fasting plasma glucose （FPG）, fasting insulin （FINS）, total cholesterol （TC）, total triglyeeride （TG） , high- density lipoprotein （HDL） , low-density lipoprotein （LDL） were measured. Insulin resistance index （ HOMA IR） and β-cell function index （HOMAβ） were calculated, and multivariate logistic regression analysis was performed. As a result TG, waist hip ratio （WHR） and Ln（HOMAIR） were higher in T2DM than those in control , but Ln （HOMAβ） were lower than control（P（0.05）. The results of multivariate logistic analysis showed that cardiovascular disease history, Ln（HOMAIR） and Ln（HOMAβ） influenced the incidence of T2DM. We can draw a conclusion that T2DM patients appeare dyslipidaemia; cardiovascular disease history and Ln（HOMAIR） are risk factors, and Ln（HOMAβ） is a protective factor.