功能性胃肠病的病因和发病机制研究进展

Research Progression on the Etiology and Pathogenesis of Functional Gastrointestinal Diseases

功能性胃肠病(FGIDs)是一组常见的消化科疾病,其病因和发病机制复杂繁多,与遗传和心理社会因素具有一定的关系,胃肠动力、内脏感觉、脑肠肽等在FGIDs发病中的作用已得到肯定,近年来关于炎症和肠道菌群在FGIDs中作用的研究较多,对FGIDs病因机制的阐明将使其诊断和治疗提高到一个新的水平。

FGIDs is a very common disease in gastroenterology department. Its etiologies and pathogeneses are various and complicated. Genetic factors and psychosocial factors are related to the disease. The roles of abnormal motility, visceral sensitivity and brain-gut peptides in the onset of the disease have been confirmed. The relationship among inflammation, gut bacterial flora and FGIDs has been widely researched these years. All these etiologies and pathogeneses studies about the disease will greatly improve current diagnosis and therapy levels.