补肾疏肝汤对肾虚肝郁型多囊卵巢综合征患者临床症状及性激素的影响

Effect of Nourishing Kidney and Dispersing Stagnated Hepatoqi Decoction on Symptoms and Sex Hormone of Polycystic Ovary Syndrome Patients with Renal Deficiency and Hepatic Stagnation

目的观察补肾疏肝汤对肾虚肝郁型多囊卵巢综合征(PCOS)患者临床症状改善情况及对性激素的影响。方法56例患者分为中药组(30例,服用补肾疏肝汤)和达英组(26例,服用达英-35),观察用药前后的月经情况、痤疮及多毛症状,同时观察不良反应;超声监测测量治疗前后两侧卵巢的卵泡数,并按照椭圆法测量卵巢体积;检测治疗前后血清黄体生成素(LH)、卵泡刺激素(FSH)、雌二醇(E2)、睾酮(T)水平。结果中药组在治疗过程中有2例妊娠。月经稀发、痤疮2组治疗后比治疗前明显改善(P<0.05)。达英组部分患者有不良反应,中药组未见不良反应。2组患者双侧卵巢体积明显缩小,卵泡数目亦明显减少(P<0.05)。血清LH、T、LH/FSH值2组治疗后均较治疗前明显降低(P<0.05);各激素水平2组治疗后比较差异无显著性意义(P>0.05)。结论补肾疏肝汤可改善肾虚肝郁型PCOS患者的临床症状和内分泌情况,且无明显不良反应。

Objectives To observe the effect of the nourishing kidney and dispersing stagnated hepatoqi decoction （NKD） on symptoms and sex hormone of polycystic ovary syndrome patients with renal deficiency and hepatic stagnation. Methods Fifty six patients were divided into two groups： the NKD group （30 cases, treated with the NKD）, and the Diane-35 group （26 cases, treated with Diane-35）. Condition of menstruation, acne, hairiness and side effects were observed. The follicle figures and ovary volume were recorded, and the sex hormone were detected before and after treatment. Results Two patients were pregnancy in NKD group. After treatment, the condition of menstrual disorder and acne were improved significantly in both groups （P〈0.05）. Some patients in Diane-35 group had adverse reaction, while no adverse reaction in NKD group. The follicle figures were lessed, and ovary volumes were decreased in both groups （P〈0.05）. LH, LH/FSH and T decreased in both groups （P〈0.05）. Conclusions NKD could improve symptoms and sex hormone of polycystic ovary syndrome patients with renal deficiency and hepatic stagnation, and had no side effects.