转化生长因子β_1与结缔组织生长因子在幽门螺杆菌相关性胃炎中的研究

In situ correlation of transforming growth factor β_1,connective tissue growth factor in H.pylori-associated atrophy gastritis

目的研究转化细胞因子(TGF-β1)和结缔组织生长因子(CTGF)在胃窦部不同病变中的表达情况,并探讨它们与幽门螺杆菌(H.pylori)相关性胃炎之间的关系。方法采用免疫组化的方法对于70例H.pylori阳性及58例H.pylori阴性共计128例的胃窦组织进行检测。结果相比H.pylori阴性患者,H.pylori阳性患者胃窦部的TGF-β1及CTGF表达水平都显著升高。TGF-β1及CTGF表达水平与慢性胃炎的萎缩程度呈正相关。结论H.pylori感染后,TGF-β1及CTGF在过度纤维化及萎缩性胃炎发生发展中起重要作用。

Objective Transforming growth factor β1 （TGF-β1） and connective tissue growth factor （CTGF） play important roles in Helicobacter pylori （H. pylori） associated gastritis. This study intended to examine the in situ expressions of these cytokines in gastric antrum with or without H. pylori infection. Methods Antral specimens from 128 patients were used in this study. Immunohistochemistry was used to demonstrate local expressions of TGF-β1 and CTGF in gastric antrum. Results The results demonstrated that mononuclear cells （MNCs） in lamina propria were major source of these cytokines. The number of MNCs stained with TGF-β1 and CTGF was significantly higher in H. pylori-positive patients than in H. pylori-negative patients. Furthermore,there were positive correlations between these cytokine producing MNCs and severity of chronic gastritis. Conclusion H. pylori infection is associated with increased expression of TGF-β1 and CTGF in gastric antrum. The results also imply that TGF-β1 and CTGF may play important role in the pathogenesis of H. pylori associated gastritis.