川芎嗪注射液对Ⅱ型糖尿病胰岛素拮抗因子的影响

The effects of chuanxiongqin injection on diabetic insulin rivalry factors

目的探讨Ⅱ型糖尿病胰岛素抵抗及其与C反应蛋白（CRP）、肿瘤坏死因子（TNF-α）和内皮素-1（ET-1）水平的关系，通过观察川芎嗪注射液对Ⅱ型糖尿病胰岛素抵抗的影响，初步探讨川芎嗪注射液对Ⅱ型糖尿病胰岛素抵抗的影响及机制。方法比较Ⅱ型糖尿病患者100例与正常人群30例的血清C反应蛋白（CRP）、肿瘤坏死因子（TNF-α）和内皮素-1（ET-1）水平；将Ⅱ型糖尿病患者100例随机分为中西药治疗组（A组）和常规治疗组（B组），每组各50例。2组患者分别于治疗前后测定空腹血糖、餐后2h血糖、血清C反应蛋白（CRP）、肿瘤坏死因子（TNF-α）和内皮素-1（ET-1）水平。比较2组患者治疗前后上述指标的变化。结果Ⅱ型糖尿病患者的血清C反应蛋白（CRP）、肿瘤坏死因子（TNF-α）较正常人群升高，内皮素-1（ET-1）降低（P〈0．05）。A组患者血糖控制达标时间较B组缩短，有显著性差异（P〈0．05）；A组血清C反应蛋白（CRP）和肿瘤坏死因子（TNF-α）降低、而内皮素-1（ET-1）升高，较B组有显著性差异（P〈0．01）。结论Ⅱ型糖尿病胰岛素抵抗与其与C反应蛋白（CRP）、肿瘤坏死因子（TNF-α）呈正相关，与内皮素-1（ET-1）呈负相。川芎嗪注射液通过有效的改善糖尿病患者的胰岛素拮抗因子，提高患者对胰岛素的敏感性，缩短血糖控制达标时间。

Objective To study the relationship between type Ⅱ diabetes mellitus＇s insulin resistance and C-reactive protein（CRP）, tumor necrosis factor（TNF-α）. endothelium-1（ET-1） level, and through observe the effect of Chuanxiongqin injection on insulin resistance ,to initial investigate the effect and mechanism about Chuanxiongqin injection on type Ⅱ diabetes mellitus＇s insulin resistance. Methods The first：to collect 100 patients with type 2 diabetes mellitus and 30 health subjects in our hospital. The second：100 type Ⅱ diabetes mellitus patients were randomly divided into group A（conbined treatment of traditional Chinese medicine and western medicine）and group B （conventional therapy）, every group had 50 patients and to determine fasting blood sugar, postprandial 2 hour blood sugar, C-reactive protein（CRP）, tumor necrosis factor（TNF-α）and endothelium-1（ET-1） levels about before and after treatment, to compare the indexes in the two groups. Resuits The C-reactive protein（CRP）, tumor necrosis factor（TNF-α） were obviously higher in the diabetic patients than in the healthy control group, but endothelium-1（ET-1） obviously lower（P〈0. 05）, The time of blood sugar in suitable standard in group A was superior to that in group B（P〈 0.05）, C-reactive protein（CRP）, tumor necrosis factor（TNF-α）, endothelium-1（ET-1） in group A increased. And the improvement in group A was superior to that in group B （P〈0.01）.Conclusion The type Ⅱ diabetes mellitus＇s insulin resistance was positively correlated with C-reactive protein（CRP）, tumor necrosis factor（TNF-α）,but negatively correlated with endothelium-1（ET-1）. Chuanxiongqin injection has a certain effect in improving insulin rivalry factors in diabetic patients and raising insulin sensitivity, decurtating the time of blood sugar in suitable standard.