PGE1对慢性肾衰患者血管舒缩肽类物质的影响及其临床意义探讨

The approach to the clinical significance of Prostaglandin E1 effct on the chronicity renalfailure patient＇s vasomotion peptide substance

目的了解前列腺素E1（Prostaglandirl E1，PGE1）对慢性肾功能衰竭（chronic renal failure，CRF）患者血管舒缩肽的影响及其临床意义。方法将47例cRF患者随机分为常规治疗组（23例）和前列腺素E1（PGE1）治疗组（24例）。常规治疗组给予低蛋白饮食、能量及维生素，血压高者口服降压药，血糖高者给予普通胰岛素，贫血者给予促红细胞生成素、糖酐亚铁片及对症治疗。PGE1治疗组在常规治疗组的治疗基础上给予PGE1，10ug／次／d，14d为一疗程。并对两组治疗前后的血管舒缩肽类物质[一氧化氮（N0）、内皮素（ET）、血栓素B2（TXB2）、6-酮-前列腺素F1a（6-Keto-F1a）]及尿素氮（BUN）、血清肌酐（Scr）、临床疗效进行比较。结果两组治疗后NO、6-Keto—F1a均显著升高，ET、TXB2／6-Keto—F1a及BUN、Scr均显著降低，两组治疗后均较治疗前有所改善（其中常规治疗组P〈0．05、PGE，治疗组P〈0．01）。两组间比较，PGE1治疗组明显优于常规治疗组（P〈0．05），PGE-治疗组的总有效率显著优于常规治疗组（P〈0．05），TXB2两组治疗前后均变化不显著。结论PGE，能通过对CRF患者的血管舒缩肽类物质的调节改善患者肾功能，从而发挥对CRF的治疗作用。

Objective To study the clinical significance of Prostaglandin E1（PGE1） effct on the chronicity renalfailure（CRF） patient＇s vasomotion peptide substance. Methods 47 chronicity renalfailure patients were randomly choosed from 23 patients as the conventional therap and chossed from 24 patients as the Prostaglandin E1 therapy group, the conventional y group erapy group supply low protein diet, low-protein diet, energy and vitamin, take orally the AI XI TE tablet, those who＇s blood pressure is high enalapril meleate, those who＇s blood glucose is high Admin regular insulin, those who anaemia Admin EP0, glyco- Anh-ferro- tablet and symptomatic treatment. The Prostaglandin E, therapy group was based on the conventional therapy group Admin the Prostaglandin E1,100g one time per day, 14d for one time of therapy. And contrast with the two groups include of pretberapy and post-treatment patient＇s vasomotion peptide substance （nitrogen monoxidum（NO）,endotbelin（ET）, thromboxaneB2（TXB2）,6-ketone-Prostaglandin F1a （6-Keto- F1a）,urea nitrogen （BUN）,blood-serum Crea （Scr）,clinic therapeutic effect. Results The NO and 6-Keto- F1a content in blood serum of two groups post-treatment all increased remarkably, while the ET, TXB2/6-Keto-F1a, BUN and Scr content in blood serum all decreased remarkably, but the Prostaglandin E1 therapy group prominently surpass than the conventional therapy group , contrast the two groups of pretherapy and post-treatment, the conventional therapy group P〈0. 05, the Prostaglandin E1 therapy group P〈0.01, the two groups of post-treatment compare with that the two groups of pretherapy P〈0.05, and the Prostaglandin E1 therapy group total effective rate prominently surpass than the conventional therapy group （P〈0.05）, the two groups of TXB2 pretherapy and TXB2 post-treatment didn＇t change remarkably. Conclusion The PGE1 can adjustment and improved patient, s renal educe the therapeutical effect of CRF patients.