骨转移癌不同剂量分割放疗止痛疗效分析

The observation of radiotherapy of bone metastases with difference fraction

目的探讨不同分割剂量放疗对骨转移癌止痛的疗效。方法62例骨转移癌病人共82个病灶采用两种不同分割剂量放疗。常规分割放疗组33例，每次2Gy，每周5次，总剂量30～40Gy／3～4周；非常规分割放疗组29例，每次3Gy，每周5次，总剂量30Gy／2周。结果常规分割放疗组完全缓解（CR）率70．5％，部分缓解（PR）率20．5％，总有效率90．9％；非常规分割放疗组完全缓解（CR）率62．2％，部分缓解（PR）率21．6％，总有效率83．8％。组间比较差异无显著性（P〉0．05）。结论不同分割剂量放疗对骨转移癌疼痛的缓解程度无影响，采用何种分割方式应根据病情及生存期长短来决定。

Objective To evaluate the effect of pain control with radiotherapy received 2 fr in bone metastases from malignancies. Methods 62 actionati fractions： DT 2 Gy/f, different fractionated dose of cases with 82 bone metastases on schedules of radiotherapy： 33 cases were performed with conventional 5 fractions per week, DT 30-40GY/3-4w;29 cases were performes with unconventional： DT 3 GY/f, 5 fractions per week, DT 30GY/2w. Results Complete relief（CR） rate of conventional fraction group were 70.5% partial relief （PR） were 20.5% Pain relief rate （CR＋PR） were 90.9%;CR, PR, CR＋PR of unconventional fraction group were 62.2%, 21.6%, and 83.3% respectively. No significant difference was found （P〉0.05）.Conclusion Different fractionated dose of radiotherapy have no influence on pain relief in bone metastases. The principle of radiotherapy should be determined by the patient condition and expected life span.