紫杉醇联合顺铂治疗非小细胞肺癌的45例临床研究

Clinical study of taxel plus DDP in the treatment of nonsmall-cell lung cancer （NSCLC）

目的 探讨紫杉醇＋顺铂联合化疗方案对非小细胞肺癌的临床疗效和安全性。方法45例患者给予紫杉醇75mg／m^2 i．v．d1＋顺铂80mg／m^2 i．v，分3天用，每21天为1周期。结果 入组的45例中，治疗后完全缓解（CR）3例，占6．70％，部分缓解（PR）24例，占53．33％，无变化（NC）15例，占33．33％，总有效率CR＋PR为60．00％；不良反应主要有中性粒细胞减少、贫血、粒细胞减少性发热、其他发热、脱发、恶心呕吐和乏力。结论 紫杉醇＋顺铂联合化疗方案对非小细胞肺癌有一定疗效，且毒性可耐受。

Objective To investigate the effects and side effects of Taxel plus Cisplatin regimens in patients suffered from non small-cell lung cancer（NSCLC）.Methods 45 patients suffered from NSCLC treated by Taxel 75mg/m^2 i.v. dl plus Cisplatin 80mg/m^2 i.v, every 3 weeks.Results The effective rate（CR＋PR） was 60.00%,tne major anemia, febrile neutropenia, fever, alopecia, nausea, vomiting and fatigue. Conclusion Taxel plus cisplatin regimens is an effective and well-tolerated treatment in patients suffered from NSCLC