外用博莱霉素凝胶治疗尖锐湿疣的疗效及不良反应初探

The research of the effect curing the condylomata acuminata by external bleomycin gel

目的 探讨外用博莱霉素凝胶治疗尖锐湿疣的疗效和不良反应。方法 采用随机、平行对照临床研究方法，共入选尖锐湿疣患者180例，随机分为治疗组和对照组各90例，治疗组用0．2％博莱霉素凝胶剂；对照组用2．5％氟尿嘧啶乳膏；同时外搽，每周3次，最长疗程8周；同时观察治疗效果与不良反应。痊愈后继续随访8wk，以观察复发率。结果治疗组的痊愈率81．1％；有效率90．0％；痊愈后复发7例，复发率9．6％；对照组的痊愈率68．9％；有效率80．0％；痊愈后复发13例，复发率21．0％。治疗组不良反应主要为给药部位的红斑、水肿和瘙痒，无系统不良反应。结论 外用博莱霉素凝胶治疗尖锐湿疣疗效果优于对照组，不良反应发生率和程度都明显低于对照组。

Objective To probe into the clinical therapeutic effectiveness and safenes bleomycine gel in the topical treatment of condyloma acuminatum. Method A randomized parallet-controlled clinical study was carried out. One hundred eighty patients condyloma acuminatum enrolled into the trial were randomly divided into 2 groups： the treatment group（n=90）, control group （n=90） Patients of the treatment group were given 0. 2% bleomycine gel qs , control group were given 2.5% 5- fluorouracil cream qs, respectively, administered by topical smearing 3 times a week. The course of treatment in 2 groups lasted 8 weeks. Patients whose warts had been cleared up completely were followed up for 8 weeks for checking on recurrence rates. Result The cure rates were 81.1% and the effective rates were 90.0% in patients of the treatment group, but 7 patients in the treatment group .The cure rates were 68.9% and the effective rates were 80.0% in patients of the control group, but 7 patients in the treatment group experienced recurrences of warts after complete recovery, the recurrence rates being 9.6% and 13 patients in the control group experienced recurrences warts after complete recovery, the recurrence rates being 21.0%.Adverse reactions were countered in 13 patients（14.4%） of the treatment group and adverse reactions were countered in 24 patients（26.7%） of the control group. Themajor adverse reactions in patients of the treatment group included erythema, oedema and tickle in the topical areas where the drug was smeared. There were no systemic adverse reactions in patients of the treatment groups. Conclusion Bleomycine gel was shown to be effective, safe and handy in the topical treatment condyloma acuminatum.