摘要
B细胞特异的莫洛尼白血病毒插入位点1基因(Bmi-1)是属于转录抑制因子多疏基基因家族中的成员之一,Bmi-1在调节干细胞自我更新、细胞增殖和衰老中发挥重要作用。近年来研究发现,Bmi-1在多种肿瘤中表达异常,在肿瘤的发生、发展中发挥重要作用。体外实验证明,干扰Bmi-1表达可显著抑制肿瘤细胞增殖。
B-cell specific moloney leukemia virus insertion site 1 （ Bmi-1 ） gene is a member of polycomb group （PcG） gene family acting as transcription inhibitory factor. Bmi-1 plays an important role in the regulation of self-renewal in stem cells, proliferation and aging in cells. Latest reports indicated that abnormal expression of Bmi-1 exists in various tumors and plays an important role in the tumor genesis and progress. In vitro experiments proved that interference of the expression of Bmi-1 gene could potently inhibit tumor cell proliferation.
出处
《医学综述》
2008年第9期1293-1294,共2页
Medical Recapitulate
