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肝脂酶与糖尿病及动脉粥样硬化的关系 被引量：3

The Relationship of Hepatic Lipase with Diabetes or Atherosclerosis
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摘要 肝脂酶(HL)是脂蛋白代谢的关键酶之一,主要在肝细胞中合成,能水解各种脂蛋白中的三酰甘油和磷脂。肝脂酶基因(LIPC)变异是影响HL合成、活性改变的主要原因。LIPC启动子区有4个常见的呈连锁遗传的单核苷酸基因多态性,即-250G→A、-514C→T、-710T→C和-763A→G。LIPC的单核苷酸基因多态性与糖尿病、动脉粥样硬化等多种疾病具有相关性。 Hepatic lipase is one of key enzyme during lipoprotein metabolism, which is mainly synthesized in live cells and can hydrolyze triacylglycerol and phospholipid of all kinds of lipoprotein. The mutation of hepatic lipase gene is the main reason affecting the synthesis and activity changes of HL. The four common found single-chain genetic gene nucleofide polymorphism（SNP） in the promoter region of LIPC are -250G→ A, -514C→T, -710T→C and -763 A→G. The SNP of hepatic lipase gene is associated with diabetes, athero- sclerosis and other diseases.
作者 王苑铭 田林红 陈慧 张娟
机构地区 兰州大学第二医院内分泌科
出处 《医学综述》 2008年第9期1365-1367,共3页 Medical Recapitulate
基金 甘肃省中医药科研项目
关键词 肝脂酶 糖尿病 脂蛋白代谢 动脉粥样硬化 肝脂酶基因多态性 Hepatic lipase Diabetes Lipoprotein metabolism Atherosclerosis Hepatic lipase gene polymorphism
分类号 R587.1 [医药卫生—内分泌] R543.5 [医药卫生—心血管疾病]
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参考文献24

  • 1Zambon A,Deeb SS,Pauletto P,et al. Hepatic lipase:a marker for cardiovascular disease risk and response to therapy[J]. Curr Opin Lipidol,2003,14 (2) : 179-189.
  • 2肝脂酶基因多态性是1型糖尿病男性患者高密度脂蛋白水平及其颗粒大小的主要决定因素（79—OR）[J].国外医学（内分泌学分册）,2002,22(6):407-407. 被引量：1
  • 3Pihlajamaki J, Karijainen L, Karhapaa P, et al. G-250A substitution in promoter of hepatic lipase gene is associated with dyslipidemia and insulin resistance in healthy control subjects and in members of families with familial combined hyperlipidemia[ J]. Arterioscler Thromb Vasc Biol,2000,20(7) :1789-1795.
  • 4Jansen H,Waterworth DM,Nicaud V,et al. Interaction of the common apolipoprotein C-Ⅲ ( APOC3 -482C > T) and hepatic lipase (LIPC -514C > T) promoter variants affects glucose tolerance in young adults. European Atherosclerosis Research Study Ⅱ ( EARS- Ⅱ) [J]. Ann Hum Genet,2001,65(3) :237-243.
  • 5Yabu Y,Noma K,Nakatani K,et al. C-514T polymorphism in hepatic lipase gene promoter is associated with elevated triglyceride levels and decreasing insulin sensitivity in nondiabetic Japanese subjects[J]. Int J Mol Med,2005,16(3) :421-425.
  • 6Gomez P, Perez-Jimenez F, Marin C ,et al. The -514 C/T polymorphism in the hepatic lipase gene promoter is associated with insulin sensitivity in a healthy young population [ J ]. J Mol Endocrinol, 2005,34(2) :331-338.
  • 7Zambon A, Deeb SS, Hokanson JE, et al. Common variants in the promoter of the heptic lipase gene are associated with lower levels of hepatic lipase activity, buoyant LDL, and higher HDL2 choleaterol [ J ]. Arterioscler Thomb Vasc Biol, 1998, 18 ( 11 ) : 1723 -1729.
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二级参考文献25

  • 1鄢盛恺,周新,哈黛文.聚合酶链反应限制性片段长度多态性检测载脂蛋白E基因型[J].中华医学检验杂志,1997,20(1):28-31. 被引量：60
  • 2Hubacek JA , Waterworth DM , Pitha J , et al . Polymorphisms in the lipoprotein lipase and hepatic lipase genes and plasma lipid values in the Czech population. Physiol Res, 2001, 50:345-351.
  • 3Inazu A, Nishimura Y, Terada Y, et al . Effects of hepatic lipase gene promoter nucleotide variations on serum HDL cholesterol concentration in the general Japanese population. J Hum Genet, 2001, 46:172-177.
  • 4Hegele R, Harris J, Brunt T, et al. Absence of association between genetic variation in the LIPC gene promoter and plasma lipoproteins in three Canadian populations. Atherosclerosis, 1999, 146:153-160.
  • 5Todorova B, Kubaszek A, Pihlajamaki J, et al. The G-250A promoter polymorphism of the hepatic lipase gene predicts the conversion from impaired glucose tolerance to type 2 diabetes mellitus: the Finnish Diabetes Prevention Study. J Clin Endocrinol Metab , 2004, 9:2019-2023.
  • 6Fang DZ, Liu BW. Polymorphism of HL +1075C, but not -480T, is associated with plasma high density lipoprotein cholesterol and apolipoprotein AI in men of a Chinese population. Atherosclerosis, 2002, 161:417-424.
  • 7Tan KC, Shiu SW, Chu BY. Effects of gender, hepatic lipase gene polymorphism and type 2 diabetes mellitus on hepatic lipase activity in Chinese. Atherosclerosis, 2001, 157:233-239.
  • 8Couture P, Otvos JD, Cupples LA, et al. Association of the C-514T polymorphism in the hepatic lipase gene with variations in lipoprotein subclass profiles: The Framingham Offspring Study. Arterioscler Thromb Vasc Biol, 2000, 20:815-822.
  • 9Ji J, Herbison CE, Mamotte CD, et al. Hepatic lipase gene -514 C/T polymorphism and premature coronary heart disease . J Cardiovasc Risk, 2002, 9:105-113.
  • 10Tahvanainen E,Syvanne M,Frick MH,et al.Association of variation in hepatic lipase activity with promoter variation in the hepatic lipase gene.The LOCAT Study Invsestigators.[J].J Clin Invest,1998,101(5):956-960.

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医学综述
2008年 第9期

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