卡维地洛治疗扩张型心肌病心力衰竭的临床观察

Clinical Therapeutic Observation of Carvedilol on Congestive Heart Failure in Patients with Dilated Cardiomypathy

目的观察卡维地洛对扩张型心肌病心力衰竭的治疗效果。方法40例扩张型心肌病心力衰竭患者随机分为治疗组和对照组,每组20例。对照组应用血管紧张素转换酶抑制剂、利尿剂和洋地黄及硝酸盐制剂,治疗组在对照组基础上加用卡维地洛治疗6个月。治疗前后采用超声心动图测定左心室舒张末期内径、左心室收缩末期内径和左室射血分数。结果治疗6个月后,两组患者心功能较治疗前均明显改善。治疗组LVDd、LVDS显著低于对照组,差异有统计学意义(P<0.01),LVEF显著高于对照组,差异亦有统计学意义(P<0.01)。结论卡维地洛能显著改善扩张型心肌病心力衰竭患者的心功能。

Objective To investigate the clinical effects of carvedilol on patients with congestive heart failure（CHF）. Methods 40 patients with CHFhe was divided into two groups according to the random and control principle. They are therapeutic group and control group, each group has 20 cases. The patients in control group were treated with Angiotensin-Converting enzyme inhibitor, diuretics, digitalis and nitroglycerin. The patient in therapeutic group was treated with carvedilol additional for 6- month besides the drugs used in control group. All patients had the examination of ultrasoundcardiogram before and after the therapy. The indexes observed are LVDD, LVES, LVEF. Results After the therapy of 6-month, All patients in two groups had better heart function than that before therapy. LVDd,LVDS of therapeutic group were lowered obviously than that of control group. The difference had statistical significance （P 〈 0.01 ）. while, LVEF of therapeutic group was higher obviously than that of control group. The difference also had statistical significance （P 〈 0.01 ）. Conclusion Carvedilol can obviously promote the heart function of patients with dilated cardiomyopathy having congestive heart failure.