喘息性支气管炎与儿童哮喘相关性的初步探讨

Preliminary observation on the association of asthmatic bronchitis and child asthma

目的探讨喘息性支气管炎与儿童哮喘的相关性,为喘息性支气管炎的早期干预提供试验室依据。方法用ELISA方法测定血浆总IgE,伊红染色法检测EOS计数。结果(1)喘息性支气管组血浆总IgE(T-IgE)和EOS计数均高于正常对照组(P<0.05),低于哮喘急性发作组(P<0.05)。(2)哮喘组血浆IgE和EOS计数明显高于正常对照组(P<0.01)。(3)哮喘发作组和喘息性支气管炎组的血浆总IgE和EOS计数之间都有正相关关系(r=0.750,0.573,P<0.01)。结论喘息性支气管炎和哮喘存在有部分相同的发病机制。对评分小于5分的喘支患儿,如EOS计数和血浆总IgE升高,并且具有特应性体质的,则应尽早按哮喘进行预防干预。

Objectives To investigate the relationship between asthmatic bronchitis and child asthma, in order to provide laboratory evidence for the early intervention of asthmatic bronchitis. Methods The plasma concentration of total IgE was detected with enzyme linked immunosorbent assay （ELISA）, the peripheral blood eosinophil （EOS） count was determined with eosin staining method. Results （1） The total plasma concentration of IgE and the EOS count of the asthmatic bronchitis were higher than those of control group （P〈0.05）, and lower than the asthma acute episode group （P〈0.05）. （2） The plasma concentration of total IgE and the EOS count of the asthma acute episode group were significantly higher than the normal control group （P〈0.01）. （3） There were a positive correlation between the total IgE and the EOS count （r=0. 750,0. 573, P〈0.01）. Conclusion The pathogenesis between asthmatic bronchitis and child asthma is partial same. We should carry out prophylactic intervention measure according to the management principle of asthma to the score〈5 of asthmatic bronchitis who has elevated total immunoglobulin E （IgE） and eosinophilia and characterized atopic subjects.