功能化离子液体[bmim]OTs催化乙酰化反应

Acetylation Catalyzed by Functionalized Ionic Liquid OTs

以离子液体1-丁基-3-甲基咪唑四氟硼酸盐([bmim]BF4)为溶剂,对甲基苯磺酸根(OTs-)为阴离子的功能化离子液体[bmim]OTs为催化剂进行苯甲醇的乙酰化反应.结果表明,该体系循环使用10次后仍能保持良好的催化活性和稳定性,并对各种(伯、仲、叔)醇类、酚类和胺类化合物的乙酰化反应表现出良好的普适性.核磁共振波谱(13C NMR)分析结果表明,具有亲核性的[bmim]OTs和酰化试剂乙酸酐(Ac2O)形成的活性中间体AcOTs,是催化反应的活性物种.

The functionalized ionic liquid of 1-butyl-3-methylimidazolium toluene-p-sulfonate （[bmim]OTs） dissolved in 1-butyl-3-methylimidazolium tetrafluoroborate （[bmim]BF4） can efficiently catalyze the acetylation of benzyl alcohol under neutral reaction conditions. It shows high activity and stability even after recycling use ten times. A multicomponent ionic liquid system, [bmim]OTs-[bmim]BF4, exhibits good universality to various substrates such as alcohols （primary, secondary, and tertiary）, phenols, and amines. The formed intermediate of AcOTs derived from the reaction between [ bmim]OTs and acetic anhydride （Ac2O） is the catalytically active species with the supportive information from ^13C NMR analysis.