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甲真菌病患者外周血淋-巴细胞免疫表型的分析

Analysis of lymphocyte immunophentypes in peripheral blood of onychomycosis patients with flow cytometry
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摘要 目的探讨甲真菌病患者外周血淋巴细胞免疫表型的情况。方法应用流式细胞仪对24例甲真菌病患者及20例健康人的外周血淋巴细胞亚群和自然杀伤细胞进行测定与分析。结果甲真菌患者外周血CD8^+淋巴细胞明显高于健康对照组(P〈0.05),而CD3^+细胞,CD4^+细胞,CD4^+/CD8^+、CD19^+细胞、CD16^+CD56^+细胞与对照组变化不明显。结论甲真菌患者存在着一定程度的细胞免疫异常,以CD8^+细胞介导的免疫反应占主要地位。 Objective To evaluate the immunological competence in peripheral blood of the patients with onychomycosis. Methods The lymphocyte subpopulations and natural killer cells in the peripheral blood of 24 patients and a control group of 20 individuals were analysed by flow cytometry. Results The percentage of suppressor CD8 ^+ lymphocytes in the patients were significantly higher than that in the normal controls (P 〈0.05 ). No statistically significant difference was obtained in the percentages of CD3 ^+ lymphocytes, CD4^+ lymphocytes, CD19^+ lymphocytes, CD16^+, CD56^+ lymphocytes. Conclusion CD8 ^+ lymphocytes plays an importand role in mediating the cell mediated immunity in onyehomyeosis.
出处 《国际免疫学杂志》 CAS 2008年第1期8-9,共2页 International Journal of Immunology
关键词 甲真菌病 淋巴细胞亚群 流式细胞仪 Onychooycosis Lymphocytes subpopulations Flow cytometry
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