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B7-H4与肿瘤关系的研究进展 被引量：2

Development of Relationship between B7-H4 and Tumor
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摘要 T细胞介导的免疫应答在肿瘤免疫中起到重要作用，而T细胞的活化过程又依赖于双信号和细胞因子，其中活化的第二信号来自协同刺激分子，协同刺激分子中B7／CD28家族成员在肿瘤免疫中发挥着重要作用。B7家族新成员B7-H4是T淋巴细胞免疫应答的负性调控因子，可抑制T细胞的增殖和细胞因子的产生，其与肿瘤的发生发展有着重要的关系，可作为肿瘤诊断和治疗的新靶点。 T cell-mediated immune responses play an important role in tumor immunity. T-cell activation relies on double-signal and cytokines functions, and co-stimulatory molecules are the second signal of activation, B7/CD28 family members of co-stimulatory molecules play a major role in tumor immunity. B7-H4 is a new member of B7 family, and it is a negative factor in T lymphocyte immune response. B7-H4 can inhibit proliferation of T lymphocytes and the production of cytokines. BT-H4 is associated with the generation and progression of tumor , it may be a new target in the diagnosis and treatment of tumor.
作者 傅振坤 章婕 李殿俊
机构地区 哈尔滨医科大学免疫学教研室
出处 《国际免疫学杂志》 CAS 2008年第1期32-34,共3页 International Journal of Immunology
基金 黑龙江省科技厅省攻关课题资助（GB05C402-03）
关键词 B7-H4 肿瘤 T细胞 治疗方法 B7-H4 Tumor
分类号 R730.2 [医药卫生—肿瘤]
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参考文献18

  • 1Sica GL , Choi I H , Zhu G, et al. B7-H4 , a molecule of the B7 family ,negatively regulates T cell immunity . Immunity , 2003,18 (6) :849-861.
  • 2Prasad DV ,Richards S ,Mai XM, et al. B7S1 ,a novel B7 family member that negatively regulates T cell activation. Immunity ,2003, 18 (6):863-873.
  • 3Zang X,Loke P ,KimJ, et al. B7x :a widely expressed B7 family member that inhibits T cell activation. Proc Natl Acad Sci USA , 2003 , 100 (18) :10388-10392.
  • 4Hirotsune S , Yoshida N ,Chen A, et al. An expressed pseudogene regulates the messenger-RNA stability of its homologous coding gene. Nature ,2003 ,423(6935) :26-28.
  • 5Tringler B, Zhuo S, Pilkington G, et al. B7-H4 is highly expressed in ductal and lobular breast cancer. Clinical Cancer Res, 2005,11 (5) :1842-1848.
  • 6Sadun RE, Sachsman SM, Chen X,et al. Immune signatures of murine and human cancers reveal unique mechanisms of tumor escape and new targets for cancer immunotherapy. Clin Cancer Res, 2007 , 13 ( 13 ) :4016-4025.
  • 7Salceda S, Tang T, Kmet M, et al. The immunomodulatory protein B7-H4 is overexpressed in breast and ovarian cancers and promotes epithelial cell transformation. Exp Cell Res, 2005,306 ( 1 ) : 128- 141.
  • 8Tringler B, Liu W, Corral L, et al. B7-H4 overexpression in ovarian tumors. Gynecol Oncol, 2006, 100(1 ) : 44-52.
  • 9Bignotti E, Tassi RA, Calza S, et al. Differential gene expression profiles between tumor biopsies and short-term primary cultures of ovarian serous carcinomas : Identification of novel molecular biomarkers for early diagnosis and therapy. Gynecol Onco, 2006,103 (2) : 405-416.
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二级参考文献9

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  • 4Konishi J,Yamazaki K,Azuma M,et al.B7-H1 expression on non-small cell lung cancer cells and its relationship with tumor-infiltrating lymphocytes and their PD-1 expression[J].Clin Cancer Res,2004,10(15):5094-5 100.
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  • 7Prasad DV,Richards S,Mai XM,et al.B7S1,a nnovel B7 family member that negatively regulates T cell activation[J].Immunity,2003,18(6):863-873.
  • 8Sica GL,Choi IH,Zhu G,et al.B7-H4,a molecule of the B7 family,negatively regulates T cell[J].Immunity,2003,18(6):849-861.
  • 9Strome SE,Dong H,Tamurra H,et al.B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma[J].Cancer Res,2003,63(19):6 501-6 505.

共引文献13

同被引文献36

引证文献2

二级引证文献7

国际免疫学杂志
2008年 第1期

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