摘要
Toll样受体（TLRs）的发现，使人们对HBV感染免疫有了新的认识。目前研究认为，TLRs除了介导抗HBV感染天然免疫外，还能促进树突状细胞（DC）成熟，调节Th1／Th2型免疫，参与抗HBV特异性免疫，同时，HBV也影响某些TLRs的表达，这可能是HBV感染慢性化的原因之一。进一步明确TLRs在HBV感染免疫中的作用，可为HBV感染的治疗提供一个新的切入点。
The discovery of Toll-like receptors （TLRs） has helped people to gain a new understanding on the anti-HBV immunity. Recent studies showed that TLRs not only mediated the anti-HBV innate immunity, but also participated in the anti-HBV adaptive immunity by promoting the maturation of DCs and regulating TH1/TH2 immunity. But it is still doubtful it HBV affect the expression of TLRs and is one of the factors that cause the chronic HBV infection. Therefore, it is necessary to clarify the role of TLRs in HBV infection further in order to gain new insights for the prevention and treatment of HBV infection.
出处
《国际免疫学杂志》
CAS
2008年第1期43-46,共4页
International Journal of Immunology
