胃肠胰腺神经内分泌肿瘤药物治疗进展

Advances in Drug Therapy for Gastroenteropancreatic Neuroendocrine Tumors

胃肠胰腺神经内分泌肿瘤(GEP-NETs)起源于胃肠胰腺神经内分泌细胞(属APUD细胞),分泌多种活性激素,此类肿瘤的临床表现复杂多样,且恶性程度较高,极易误诊、误治。近年来GEP-NETs的治疗,特别是内科治疗取得了较大的进展,主要包括控制症状治疗、化疗、肽受体介导的放射性核素治疗、生物治疗等。本文参考国内外近期文献,就GEP-NETs的药物治疗进展作一概述。

Gastroenteropancreatic neuroendocrine tumors （GEP-NETs） are originated from neuroendocrine cells （APUD ceils） in gastroenteropancreatic tract, which can secrete various kinds of active hormones. The GEP-NETs are malignant tumors with relatively high degree, and the clinical manifestations of these tumors are complicated and variegated. Oftentimes, they are misdiagnosed and mistreated. Great advances have been made in the treatment of GEP- NETs recently, especially in medical treatment, including symptomatic treatment, chemotherapy, peptide receptor radionuclide therapy and biotherapy, etc. This article reviewed the related medical literatures both domestically and abroad with emphasis on the advances in medical treatment of GEP-NETs.