血浆尾加压素Ⅱ水平与糖尿病大血管病变的关系

Relationship between plasma urotensin Ⅱ level and macroangiopathy in patients with type 2 diabetes mellitus

目的研究血浆尾加压素Ⅱ(UⅡ)水平与糖尿病大血管病变的关系。方法103例2型糖尿病(DM)患者分为3组:①颈动脉超声正常者为DM-Ⅰ组,共39例;②颈动脉内膜-中层厚度(IMT)增厚者为DM-Ⅱ组,共27例;③颈动脉内膜粥样斑块形成者为DM-Ⅲ组,共37例。并选择31例健康者作为对照组。采用酶联免疫测定法测定血浆UⅡ含量。结果与对照组比较,DM患者血浆UⅡ水平显著增高(0.32±0.11)pg/L vs(0.55±0.22)pg/L(P=0.010),与DM-Ⅰ组比较,DM-Ⅱ组和DM-Ⅲ组的血浆UⅡ水平显著增高(0.68±0.29)pg/L,(0.59±0.24)pg/L vs(0.49±0.18)pg/L,(均P<0.01),DM-Ⅲ组血浆UⅡ水平较DM-Ⅱ组降低(P=0.01)。结论UⅡ可能参与了DM的某些代谢过程及DM大血管病变进程,特别在局部斑块形成中起作用。血浆UⅡ水平可能为提示DM并发大血管病变的一个有效指标。

Objective To study the relationship between plasma urotensin Ⅱ level and macroangiopathy in patients with type 2 diabetes mellitus（DM）. Methods One hundred and three patients with type 2 DM and 31 healthy controls were selected. According to the results of artery cartery ultrasonography, the patients with type 2 diabetes mellitus were divided into three groups, normal group （DM- Ⅰ group, n = 39）, intima-media thickness over 0.9 mm group （DM-Ⅱ group, n =27） and atheromatous plaque group （DM-Ⅲ group, n = 37）. Fasting plasma urotensin Ⅱ level was measured by radioimmunoassay. Results Mean plasma urotensin Ⅱ level in DM group was significantly higher than that in control group （0.55±0.22） pg/L vs （0.32±0.11） pg/L（ P =0. 010） ;Mean plasma urotensin Ⅱ level in DM-Ⅱ group and in DM-Ⅲ group were significantly higher than that in DM- Ⅰ group （0.68±0. 29） pg/L and （0.59±0. 24） pg/L vs （0.49±0.18） pg/L （all P 〈0. 001）. Mean plasma urotensin Ⅱ level in DM-Ⅲ group was significantly lower than that in DiM-Ⅱ group（ P =0. 01）. Conclusion A possible role for urotensin Ⅱ exists in some metabolic process and macroangiopathy progression of type 2 DM, especially acts in the formation of atheromatous plaque. Plasma urotensin Ⅱ level seems to be a useful factor to indicate macroangiopathy in patients with type 2 DM.