骨髓过氧化物酶和可溶性CD40L与急性冠脉综合征的关系

Relationship between myeloperoxidase,sCD40L and acute coronary syndrome

目的探讨血浆骨髓过氧化物酶(MPO)和可溶性CD40配体(sCD40L)与急性冠脉综合征(ACS)的关系。方法采用酶联免疫吸附法测定70例冠心病患者(ACS 50例,稳定型心绞病20例)和18例同期健康体检者(对照组)的血浆MPO和sCD40L浓度。结果ACS组MPO、sCD40L浓度明显高于稳定型心绞病组和对照组(P<0.01),稳定型心绞病组与对照组之间差异无统计学意义(P>0.05);MPO、sCD40L在单支、双支、三支病变组中均高于对照组,但在单支、双支、三支病变组之间差异无统计学意义;冠心病各亚组中MPO与sCD40L之间无明显相关性。结论AMPO和sCD40L是冠状动脉粥样硬化斑块不稳定的标志,与ACS的发生有关。

Objective To explore the relationship between plasma level of myeloperoxidase （MPO） and soluble CD40L and acute coronary syndrome. Methods 70 patients with CHD diagnosed by CAG, were divided into three subgroups according to clinical type, 50 patients with acute coronary syndrome （ ACS）, 20 patients with stable angina pectoris （SAP）. 18 normal individuals served as the control group. The plasma level of MPO and sCD40L were detected by ELISA and were compared between the groups. Results The plasma levels of MPO and sCD40L were obviously higher in ACS groups than that in SAP and control group（P 〈 0. 01 ） , The mean levels of plasma MPO and sCD40L in SAP group were not significant difference, compared with that in control group（P 〉 0. 05）. There was no obvious correlation between the level of plasma MPO and that of sCD40L . Conclusions The concentrations of MPO and sCD40L in ACS patients are increased, MPO and sCD40L correlated with the unstability of the plaque in coronary artery .