青春期PCOS患者血清C反应蛋白水平的变化及意义

Significance of Sermn C-reactive protein change in adolescence women with polycystic ovary syndrome

目的探讨青春期多囊性卵巢综合征(PCOS)患者血清C反应蛋白(CRP)水平的变化及其意义。方法对26例青春期PCOS患者(研究组)及20例正常青春期对照者(对照组)进行血清CRP及性激素检测,同时进行葡萄糖耐量试验(OGTT)及胰岛素(INS)释放试验。计算体质量指数(BMI)、空腹血糖胰岛素比率(FGIR)、糖负荷120 min血糖胰岛素比率(G120/I120)及稳态模型的胰岛素抵抗指数(HOMA-IR)。结果研究组血清T水平及LH/FSH比值、logCRP均明显高于对照组(P均<0.05);研究组BMI、空腹INS及OGTT后血糖、INS、HOMA-IR均明显高于对照组(P均<0.05),而FGIR及G120/I120均明显低于对照组(P均<0.05);Pearson相关分析显示,logCRP与BMI、HOMA-IR呈正相关(r=0.37,P均<0.05);排除BMI影响后的偏相关分析显示,logCRP与HOMA-IR仍呈正相关(r=0.28,P均<0.05),与FGIR及G120/I120呈负相关(r分别为-0.32、-0.29,P均<0.05)。结论合并IR的青春期PCOS患者血清CRP水平升高。

Objective To investigate the expression and significance of sermn C -reactive protein（CRP） in adolescence women with polycystic ovary syndrome（PCOS）. Methods 26 adolescence women with PCOS（ test group） and 20 ovulating healthy adolescence women（ controls group） were recruited. Serum CRP, sex hormone concentration, oral glucose tolerance tests （OGTT） and insulin release tests （IRT） were tested in all cases. Body mass index （BMI）, Fasting glucose to insulin ratio（ FGIR）, 2-hour glucose to insulin ratio（ G120/I120 ） and Homeostatic model assessment insulin resistance index（HOMA-IR） were calculated. Results （1） Test group presented markedly higher than controls group in T level, LH/ FSH ratio and logCRP（ all P 〈 0.05 ）. Test group presented markedly higher BMI and fasting insulin （I0） concentration, higher serum glucose, insulin after OGTT and IRT than controls group （ all P 〈 0. 05 ）. HOMA-IR increased and FGIR, G120/I120 decreased more significantly in test group than controls group （ all P 〈 0. 05 ）. Univariate analysis revealed that logCRP was significantly and positively correlation with BMI and HOMA-IR （ r = 0.37, P 〈 0.05 ）. Partial correlation showed that logCRP was positively correlation with HOMA-IR（ r = 0.28 ,P 〈 0.05） too, but significantly and negatively correlation with FGIR and G120/I120 （ r = - 0.32, - 0.29, P 〈 0.05） in test group. Conclusions Adolescence women with PCOS, who sufered from IR, had increased CRP level. It shows that chronic inflammation maybe exists in them.