前列腺素E_1联合阿米替林治疗带状疱疹后遗神经痛(附24例报告)

Clinical Observation on Lipo PGE_1 in combination with amitriptyline for Postherpetic neuralgia in patients with Herpes zoster(24 case report)

目的观察前列腺素E1脂微球载体制剂(Lipo PGE1)联合阿米替林治疗带状疱疹后遗神经痛(PHN)的疗效和安全性。方法48例PHN患者随机均分为治疗组和对照组(各24例),治疗组静脉滴注LipoPGE120μg/d及口服阿米替林25 mg/d,对照组口服阿米替林25 mg/d,疗程均为2周。结果治疗组与对照组的有效率分别为87.5%、62.5%,两组比较有显著性差异(P<0.05);治疗后1、3个月,治疗组患者疼痛积分(分别为1.57±0.98,0.56±0.82)显著低于对照组(3.33±1.52,2.01±1.13)(P<0.05);两组各有1例出现轻微不良反应,均不影响治疗。结论Lipo PGE1联合阿米替林治疗PHN安全、有效。

Objective To observe the efficacy and safety of combined therapy of Lipo PGE1 and amitriptyline in the treatment of postherpetic neuralgia of herpes zoster （PHN）. Methods 48 patients with PHN were randomly divided into treatment and control group （24 patients in each group） ： treatment group were administrated with 20 μg·d^-1 Lipo PGE1 and 25 mg·d^-1 amitriptyline for 2 weeks, control group were treated with 25 mg·d^-1 amitfiptyline for 2 weeks. Results The effective rates （ER） for treatment group and control group were 87. 5% and 62. 5% respectively. Great significances were found between two groups （ P 〈 0. 05）. Pain score of treatment group （ 1.57±0. 98, 0. 56±0. 82） was lower than that of control group （3.33±1.52, 2. 01±1.13） （P 〈0. 05） after 1 and 3 months. Slight adverse drug reactions occurred in one patient of each group, but without affecting treatment. Conclusions Combined therapy of Lipo PGE1 and amitriptyline was safe and effective for the treatment of PHN.