胃肠B细胞非霍奇金淋巴瘤病理特征及预后分析

An Correlation Analysis on Clinical Pathological Features and Prognosis of Gastrointestinal B Cell Lymphomas

目的:观察胃肠B细胞性非霍奇金淋巴瘤的临床病理特征,Bcl-2、ki-67、CD5的表达和幽门螺杆菌(Hp)的感染对其临床病理特征及预后的影响。方法:收集18例病人的临床病理资料并进行随访,通过HE及免疫组织化学染色,观察黏膜相关淋巴瘤及氵弥漫大B细胞淋巴瘤的组织学特点,检测Bcl-2、ki-67、CD5及Hp,对所得资料进行统计学分析。结果:CD5、ki-67表达及Hp感染均随着临床分期的增加而增加。Bcl-2阳性组及ki-67表达>30%组的淋巴结累及率要高于Bcl-2阴性组及ki-67表达≤30%组。CD5阳性组的生存状况要好于阴性组,而ki-67表达>30%组及Hp感染组生存状况要差于ki-67表达≤30%组及Hp未感染组。结论:Bcl-2、CD5表达、ki-67高表达及Hp感染可能与晚期淋巴瘤有关,Bcl-2表达、ki-67高表达可能与淋巴结受累有关,而ki-67表达、Hp感染与较差的生存状况相关。

Objective： To observe the clinicopathogical features expression of Bcl-2, CDS, Ki-67 and the influence of Helicobacter of gastrointestinal B cell lymphomas, pylori（Hp） infection to chnicopathogical features and prognosis of patients. Methods： The clinicopathogical data of 18 patients were collected and further follow-up was carried out. The expression of Bcl-2, CD5, Ki-67 and Hp infection were checked by using immunohistochemistry method. All of the data were statistically analyzed. Resuits： The expression of CD5, and Ki-67, and Hp infection rates increased along with the increasing of the clinical staging of the disease. The rates of lymph node involvement in the groups of Bcl-2-positive and Ki-67 higher （ 〉30% ） expression （66.67% and 77.78% ） were higher than those in groups of Bcl-2-negative and Ki-67 lower （ ≤30% ） expression （33.33% and 22.22% ）. The survival rate of CD5-positive group （ 100% ） was higher than that of CD5-negative group （50%）, while the survival rates in groups of Ki-67 higher expression and Hp infection-positive （66.67% and 33.33% ） were lower than those in groups of Ki-67 lower expression and Hp infection-negative （ 100% and 83.33% ）. Conclusion： The advanced stage of the disease seems accompanied by expression of CD5, higher expression of Ki-67 and Hp infection. Lymph node involvement associates with Bcl-2 expression and higher expression of Ki-67. Lower survival rates associate with higher expression of Ki-67 and Hp infection.