血尿酸水平与老年高血压患者颈动脉硬化关系探讨

A Study on the Relationship between Serum Uric Acid Level and Carotid Atherosclerosis in Elderly Hypertension Patients

目的:探讨血尿酸(UA)与老年高血压患者颈动脉粥样硬化病变的关系。方法:将90例老年高血压患者按血UA水平分为A组(血UA<300μmol/L)23例,B组(血UA300～399μmol/L)25例,C组(血UA400～499μmol/L)23例,D组(血UA>500μmol/L)19例,20例血UA<300μmol/L的正常老年人为对照(对照组),应用彩色多普勒超声检测其颈动脉内中膜厚度(IMT)、粥样硬化斑块,同时检测血脂、UA及C反应蛋白(CRP)。结果:高血压组的IMT较对照组明显增厚,P<0.01;动脉粥样斑块的检出率明显增高,P<0.05;且血UA高的高血压患者的IMT较血UA正常的高血压者明显增厚(P<0.05)。结论:高UA高血压、及脂质代谢紊乱均是颈动脉粥样硬化的危险因素。

Objective： To study the relationship between carotid artery atherosclerosis and blood uric acid （UA） in the elderly patient＇s with hypertension. Methods： According to the blood UA levels, 90 hypertension patients were divided into four groups： group A （UA 〈 300μmol/L, n = 23 ）, group B （300 〈 UA 〈 399 μmol/L, n = 25 ）, group C （400 〈 UA 〈 499 μmol/L, n = 23 ）, and group D （ UA 〉 500μmol/L, n = 19）. Twenty elderly patients （UA 〈 300μmol/L） without disorder of lipid metabolism or heart and cerebral vessele diseases were chosen as control group. The intima-media （IM） thickness and atherosclerotic plaque （AP） in carotid artery were checked with color Doppler ultrasound, and the blood fats, UA and C-response protein （CRP） were tested at the same time. Results： IM was thicker and the detection rate of AP was higher significantly in patients of hypertension groups than those in people of control group （P 〈 0. 01, and P 〈 0. 05 ）. IM in hypertension patients with high-UA was obviously thicker than that of hypertension patients with normal blood UA levels （P 〈 0. 05 ）. Conclusion： High uric acid, high blood pressure and lipid metabolism disorders are risk factors to carotid atherosclerosis.