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血红素加氧酶-1过表达对模拟肺移植后犬肺功能的作用研究 被引量：1

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摘要 血红素加氧酶-1（HO-1）是血红素分解代谢的限速酶，可将血红素降解为胆绿素、一氧化碳（CO）和游离Fe^2＋，多种因素如重金属、血红素、低氧、高温及紫外线照射均可诱导HO-1大量表达。因此，HO-1属于应激反应蛋白，是机体调节和抵抗氧化应激反应的重要生物分子。
作者 石缨 毕建立 宋志鸿 刘亚宁
机构地区 空军总医院中心实验室 空军总医院心胸外科 空军总医院麻醉科
出处 《中国危重病急救医学》 CAS CSCD 北大核心 2008年第5期294-296,共3页 Chinese Critical Care Medicine
关键词 血红素加氧酶 肺移植 犬
分类号 R655.3 [医药卫生—外科学]
  • 相关文献

参考文献11

  • 1Tenhunen R, Marver H S, Sehmid R. Microsomal heme oxygenase, characterization of the enzyme[J].J Biol Chem, 1969,244 (23) : 6388-6394.
  • 2Shibahara S, Mailer R M, Taguchi H. Transcriptional control of rat heme oxygenase by heat shock[J].J Biol Chem, 1987,262 (27) : 12889-12892.
  • 3Otterbein L E,Choi A M. Heine oxygenase:colors of defense against cellular stress[J].Am J Physiol lung Cell Mol Physiol,2000,279(6) :L1029-L1037.
  • 4Maines M D. The heme oxygenase system: a regulator of second messenger gases[J]. Annu Rev Pharmacol Toxicol,1997,37:517-554.
  • 5Dore S,Takahashi M,Ferris C D,et al. Bilirubin,formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury[J].Proc Natl Acad Sci USA, 1999, 96 (5): 2445- 2450.
  • 6Verma A,Hirsch D J,Glatt C E,et al. Carbon monoxide: a putative neural messenger[J]. Science, 1993, 259 (5093):381-384.
  • 7索晓华,丁春华,谭家庆,黄新莉,凌亦凌,张景坤.内源性一氧化碳对感染性休克大鼠器官保护作用及机制研究[J].中国危重病急救医学,2007,19(5):306-310. 被引量：2
  • 8Balla J, Nath K A, Balla G, et al. Endothelial cell heme oxygenase and ferritin induction in rat lung by hemoglobin in vivo [J].Am J Physiol, 1995,268(2 pt 1),L321-L327.
  • 9Katori M,Buelow R,ke B,et al. Heme oxygenase-1 overexpression protects rat hearts from cold ischemia/reperfusion injury via an antiapoptotic pathway [J]. Transplantation, 2002,73 (2) : 287-292.
  • 10Yet S F, Perrella M A, Layne M D, et al. Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice[J]. J Clin Invest, 1999,103 (8) :R23-29.

二级参考文献29

  • 1王烁,聂秀红,郭德玉,肖汉,任魁.急性肺损伤家兔早期中性粒细胞相关功能的变化研究[J].中国危重病急救医学,2004,16(7):403-408. 被引量：26
  • 2常建星,陈双,符玉茹,常瑞明,陈健文,黄子通.大鼠失血性休克复苏早期肠黏膜损伤与修复的形态学观察[J].中国危重病急救医学,2004,16(8):477-480. 被引量：15
  • 3徐杰.危重病患者肠黏膜屏障的变化与肠内营养[J].中国中西医结合急救杂志,2004,11(6):385-387. 被引量：28
  • 4吴长毅,庞庆丰,曾因明,王俊科,杨光,高新跃.大鼠血红素加氧酶-1基因在乳酸乳球菌中的表达[J].南京医科大学学报（自然科学版）,2006,26(2):101-104. 被引量：6
  • 5Wheeler A P,Bernard G R. Treating patients with severe sepsis [J]. N Engl J Med,1999,340(3):207 - 214.
  • 6Kirton O C,Windsor J,Wedderburn R,et al. Failure of splanchnic resuscitation in acutely injured trauma patient correlates with multiple organ system failure and length of stay in the ICU[J].Chest, 1998,113(4) : 1064 - 1069.
  • 7Moncure M, Chen L, Childs E W, et al. Heme oxygenase - 1 mRNA expression affects hemorrhagic shock -induced leukocyte adherence[J]. J Trauma,2003,55(1) :118 - 125.
  • 8Zuckerbraun B S,McCloskey C A,Gallo D,et al. Carbon monoxide prevents multiple organ injury in a model of hemorrhagic shock and resuscitation[J]. Shock,2005,23(6):527 - 532.
  • 9Novak F,Heyland D K , Avenell A,et al. Glutamine supplementation in serious illness:a systematic review of the evidence [J].Crit Care Med,2002,30(9) :2022 - 2029.
  • 10Uehara K,Takahashi T,Fujii H,et al. The lower intestinal tract specific induction of heme oxygenase - 1 by glutamine protects against endotoxemic intestinal injury [J]. Crit Care Med, 2005 , 33(2) :381- 390.

共引文献6

同被引文献13

  • 1陈力,黎檀实.肺泡上皮细胞在ALI、ARDS中的研究进展[J].世界急危重病医学杂志,2006,3(4):1409-1413. 被引量：3
  • 2陈娟,许峰,蒋静,方芳,匡凤梧,卢仲毅,王兴勇.氧化应激状态下肺泡Ⅱ型上皮细胞凋亡及细胞外信号调节激酶信号转导机制的研究[J].中国危重病急救医学,2007,19(4):193-196. 被引量：11
  • 3Ito K,Mizutani A,Kira S,et al.Effect of Ulinastatin,a human urinary trypsin inhibitor,on the oleic acid-induced acute lung injury in rats via the inhibition of activated leukocytea.Injury,2005,36:387-394.
  • 4Nishina K,Mikawa K,Morikawa O,et al.The effects of intravenous anesthetics and lidocaine on proliferation of cultured type Ⅱ pneumocytes and lung fibroblasts.Aneath Analg,2002,94:385-388.
  • 5Otterbein LE,Soares MP,Yamashita K,et al.Heme oxygenase-1:unleashing the protective properties of heme.Trends immunol,2003,24:449-455.
  • 6Ryter SW,Alam J,Choi AM.Heme oxygenase-1/carbon monoxide:from basic science to therapeutic applications.Physiol Rev,2006,86:583-650.
  • 7Kharbanda RK,Walton B,Allen M,et al.Prevention of inflammation-induced endothelial dysfunction:a novel vasculoprotective action of aspirin.Circulation,2002,105:2600-2604.
  • 8Grosser N,Schr(o)der H.Aspirin activates HO-1 expression in endothelial cells-role of NO/cGMP.BMC Pharmacology,2005,5:S21.
  • 9Nascimento-Silva V,Arruda MA,Barja-Fidalgo C,et al.Novel lipid mediator aspirin-triggered lipoxin A4 induces heme oxygenase-1 in endothelial cells.Am J Physiol Cell Physiol,2005,289:C557-563.
  • 10符跃强,卢仲毅,方芳,谭利平,匡凤梧,王兴勇,许峰.氧化应激诱导肺泡Ⅱ型上皮细胞凋亡及Bax和p53的表达变化[J].中国危重病急救医学,2008,20(2):76-79. 被引量：8

引证文献1

二级引证文献5

中国危重病急救医学
2008年 第5期

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