胸腺基质淋巴生成素对树突状细胞的活化作用及其在Th2型炎症中的意义

Activating effects of thymic stromal lymphopoietin on dendritic cells and its significance on the T helper type 2 inflammation

树突状细胞(dendritic cells,DCs)是体内最重要的抗原提呈细胞,其对外源性抗原的高效的加工、处理和提呈是启动T细胞应答的关键步骤;同时DCs又是免疫应答的重要调节者,不同微环境中的DCs受不同因子的作用而发生不同的成熟活化过程,从而诱导机体产生针对该环境所需要的不同的免疫应答。胸腺基质淋巴生成素(Thymic stromal lymphopoietin,TSLP)是一类优先表达于肺、肠、皮肤等上皮细胞的细胞因子,尤其在超敏反应性炎症部位表达极高。TSLP对DCs具有重要调控作用,可促进DCs的活化、成熟,增强其对CD4+T细胞的活化能力,并促使Th0细胞向Th2分化,在特应性皮炎、哮喘等炎症发生中具有重要意义。

As the most potent antigen-presenting cells （APC） in vito, dendritic cells （DCs） play critical roles in the initiation of T cell responses by processing and presenting external antigen to T cells. On the other hand, DCs are important regulators in the immune responses. DCs in different microenvironments can be activated in different ways under the influence of various cytokines, and then initiate an appropriate response adapt to the environments.Thymic stromal lymphopoietin （TSLP） is a cytokine preferentially expressed on epithelial cells in the lung, skin, and gut, especially in the lesions with allergic inflammation. TSLP can uniquely induce DCs to activate CD4^＋ T cells and produce T helper type 2 responses, which identifies TSLP as an important factor in the initiation of allergic diseases such as atopic dermatitis and asthma.