严重脓毒症和脓毒症休克患者血浆Apelin水平变化及其意义

Changes and Clinical Significance of Serum Apelin in Patients with Severe Sepsis and Septic Shock

目的初步探讨血管活性多肽Apelin在严重脓毒症和脓毒症休克患者中的血浆水平变化及其意义。方法采用酶联免疫分析法测定不同病程观察时间点(诊断当日、诊断第3日、诊断第10日)26例临床诊断严重脓毒症和脓毒症休克患者Apelin水平。结果脓毒症患者Apelin水平较健康对照显著升高(P<0·01);不同病程观察时间点间Apelin水平差异均有显著性(P<0·01);脓毒症休克患者Apelin水平较严重脓毒症患者显著升高(P<0·01)。结论血浆Apelin水平在严重脓毒症和脓毒症休克患者中存在某些变化,可能具有一定的临床意义。

Objective To explore the changes and clinical significance of serum Apelin in patients with severe sepsis and septic shock. Method We measured the serum level of Apelin with ELISA on different observation days （the 1st, 3r d, and 10th day obtaining the diagnosis） in 26 patients with severe sepsis, and septic shock. Results Serum Apelin significantly increased in sepsis patients when compared with the normal control group （P 〈 0. 01 ） ; The serum Apelin levels significantly changed among different observation days （P 〈0. 01 ）. Serum Apelin level was significantly higher in patients with septic shock than those with severe sepsis （P 〈 0. 01 ）. Conclusion Serum Apelin level changes in patients with severe sepsis and septic shock, which may provide clues in diagnosis and prognosis.