无创机械正压通气在治疗急性左心衰竭过程中对血脑钠素浓度的影响

Changes of Plasma B-type Natriuretic Peptide Level during Non-invasive Ventilation in Treating Acute Left Heart Failure

目的观察无创机械正压通气在治疗急性左心衰竭过程中对血脑钠素浓度的影响。方法将急性左心衰竭患者随机分为两组:无创通气组常规治疗左心衰竭加用无创通气15例,未用呼吸机组常规治疗左心衰竭13例。选取10例健康成年人为正常对照组。采用ELASA方法测定治疗前及治疗后3、7h血脑钠素浓度。结果未用呼吸机组、无创通气组治疗前血脑钠素浓度较正常对照组显著升高(P<0·01);未用呼吸机组治疗后3、7h较正常对照组显著升高(P<0·05),而无创通气组较未用呼吸机组显著降低(P<0·05,P<0·01)。结论血脑钠素在无创机械正压通气治疗急性左心衰竭过程中较未用呼吸机组显著下降。证明随着心功能好转,血脑钠素浓度亦显著下降。

Objective To assess the changes of B-type invasive ventilation in treating acute left heart failure. natriuretic peptide （BNP） levels during non- Totally 28 patients with acute left heart failure were randomly assigned to group A （ n = 13 ; without non-invasive ventilation） and group B （ n = 15 ; undergo- ing non-invasive ventilation）. Another 10 healthy adults were enrolled as the normal control group. Plasma BNP were obtained with ELISA before treatment and 3 and 7 hours after treatment. Results The plasma BNP levels were significantly higher in group A and group B than in the normal control group before treatment （ P 〈 0. 01 ）. Three and 7 hours after treatment, the plasma BNP levels was significantly higher in group A than in the normal control group （ P 〈 0. 05 ） , while it was significantly lower in group B than in group A （ P 〈 0. 05, P 〈 0. 01 ）. Conclusion The plasma BNP level remarkably decreases in patients undergo non-invasive ventilation, suggesting that the plasma BNP level decreases along with the improvement of cardiac function.