呼气末正压通气在重度急性有机磷农药中毒中的应用

Clinical Study on Treatment of Severe Acute Organophosphorus Poisoning with Positive End-Expiratory Pressure

目的:探讨呼气末正压通气模式在治疗重度急性有机磷农药中毒中的疗效。方法:治疗组采用呼气末正压通气模式辅助长托宁治疗30例重度急性有机磷农药中毒患者,并与对照组传统方法治疗的30例患者进行比较,动态检测胆碱酯酶(CHE)活性,观察长托宁用量、昏迷时间、机械通气时间、病死率、住院时间及并发症发生率。结果:与对照组相比,治疗组CHE恢复时间、昏迷时间、机械通气时间、并发症发生率和死亡率明显降低(P<0.05),治愈率明显升高(P<0.05)。结论:呼气末正压通气辅助治疗重度急性有机磷农药中毒疗效确切,值得临床推广。

Objective： To evaluate the therapeutic effects of positive end expiratory pressure for severe acute organophosphorus poisoning. Methods： Thirty patients with severe acute organophosphorus poisoning were treated with positive end-expiratory pressure, and another 30 cases of organo- phosphorus poisoning with traditional treatment. The changes on the choline esterase, volume of use on penehyclidine hydrochloride, duration of mechanical ventilation, time of in-hospital and cataphora, complication and mortality were compared between the two groups. Results： Treat- ment of severe acute organophosphorus poisoning with positive end expiratory pressure could reduce the occurrence of complications, decrease the coincidence time of choline esterase, duration of mechanical ventilation, length of stay and cataphora and mortality. Conclusion： It is suggested that the therapy with positive end expiratory pressure has a good effect on the patients with severe acute organophosphorus poisoning.