针刺百会、水沟穴对脑缺血大鼠抗心磷脂抗体含量的影响

Effect of Acupuncture at Baihui and Shuigou on the Content of Anticardiolipin Antibodies in Rats with Cerebral Ischemia

目的:探讨针刺百会、水沟穴治疗对脑缺血大鼠抗心磷脂抗体(ACA)含量的影响。方法:72只SD大鼠随机分成正常组、模型组、针刺组。针刺组每天针刺百会、水沟穴。分别于缺血再灌注后第1d、第3d、第7d、第14d采用酶免法测血清抗心磷脂抗体。结果:针刺组大鼠在缺血再灌注后第1d、第3d、第7dIgG型ACA水平高于正常组(P<0.05),低于模型组(P<0.05);第14d接近正常组(P>0.05)。针刺组大鼠在缺血再灌注后第1d、第3d、第7d、第14dIgM型ACA水平高于正常组(P<0.05),低于模型组(P<0.05)。结论:针刺百会、水沟穴治疗对脑缺血大鼠血清IgG型、IgM型ACA的产生有一定抑制作用。

Objective：To study the effect of acupuncture at Baihui and Shuigou on the content of anticardiolipin antibodies （ACA）in rats with cerebral ischemia.Method：72 SD rats were randomly divided into normal control group,model group and acupuncture treatment group.Treatment group was treated with acupuncture at Baihui and Shuigou.Blood samples in three groups were taken for the assay of serum ACA by enzyme immunoassay on the first,third,seventh,and fourteenth day after the model establishmenta^esults：On the first,third,seventh day after the model establishment, IgG-ACA content of treatment group was higher than that of the normal control group （P〈0.05）,but lower than that of model group（P〈0.05）. On the fourteenth day IgG-ACA content of the treatment group was close to that of normal control group （P〉0.05）.On the first,third, seventh, fourteenth day after the model establishment, IgM-ACA content of treatment group was higher than that of normal control group （P〈0.05）,but lower than that of model group （P〈0.05）.Conclusion：Acupuncture at Baihui and Shuigou has inhibitive effect on the formation of serum IgG-ACA and IgM-ACA in rats with cerebral ischemia.