摘要
目的探讨耐药基因蛋白PgP在大肠癌组织中的表达及意义。方法应用免疫组织化学方法检测48例大肠癌组织中PgP的表达,并分析其与临床病理特征的关系。结果PgP表达与淋巴结转移有关,与性别、年龄、原发肿瘤部位、肿瘤大小、分化程度、局部浸润深度、远处转移、Duker分期无关。结论临床检测大肠癌PgP表达对大肠癌化疗方案的选择具有重要的意义。
Objective To evaluate the expression of P-glycoprotein（PgP） in colorectal carcinoma and its correlation to clinic opathological features. Methods The expression patterns of PgP in 48 patients with colorectal carcinoma were examined by immunohistochemistry SP method using monoclonal antibody to their protein. Results The expression of PgP was related to lympy node metastasis. Its expression was＇t related to sex and age of the patients,localization of the primary tumor,tumor size, histological grade,local invasion, distant metastasis and Duke＇s stage. Conclusion Detecting the expression of PgP might play an important role in chemotherapy strategy of colorectal carcinoma.
出处
《中国现代医生》
2008年第13期6-7,共2页
China Modern Doctor
关键词
结肠直肠肿瘤
P糖蛋白
基因表达
临床病理特征
化学治疗
Colorectal neoplasms
P-glycoprotein
Gene expression
Clinic opathological features
Chemotherapy
