黄连素和维生素E烟酸酯治疗血脂异常的观察

Observation of Berberine Combined with Vitamin E Nicotinate in Treatment of Hyperlipemia

目的研究黄连素联合维生素E烟酸酯治疗血脂异常的疗效、安全性和经济性。方法比较60例血脂异常患者口服黄连素0.5g、2次/d+维生素E烟酸酯0.1g、2次/d(治疗组),与辛伐他汀20mg、1次/d、治疗58例血脂异常患者(辛伐他汀对照组)的疗效。结果治疗组的甘油三酯、低密度脂蛋白胆固醇,高密度脂蛋白胆固醇达标率和改变幅度均显著优于辛伐他汀对照组(P<0.05,P<0.01);对总胆固醇的降低与辛伐他汀组没有显著性差异(P>0.05);并且治疗组的副作用和患者依从性显著优于辛伐他汀对照组,每天患者的费用亦显著低于辛伐他汀对照组。结论黄连素联合维生素E烟酸酯是对血脂异常者一种有效、安全和经济的治疗组合,值得推广。

Objective To study the efficacy,safety and economy of berberine combined with vitamin E nicotinate in patients with hyperlipemia. Methods The patients with hyperlipemia（therapy group） had been orally administrated berberine 0.Sg twice/d, ＋ Vitamin E nicotinate 0.1g twice/d for 2 months,and other 58 cases had orally administrated simvastatin 20mg once/d for 2 months （simvastatin group）. Results The control rates and improved amplitudes of the TG,LDL-C and HDL-C in therapy group were significantly more than those of simvastatin group（P〈 0.05 ,P〈 0.01 ）; but there was no significant difference of TC between therapy group and simvastatin group（P〉 0.05）; the cost of therapy group was significant lower than that of simvastatin group. Conclusion The berberine combined with Vitamin E nicotinate is an effective, safe and economic therapy for hyperlipemia.