前列腺增生患者年龄、前列腺体积以及血清PSA的关系分析

Study on the relationship between age,prostate volume and prostate specific antigen of patients with benign prostatic hyperplasia

目的探讨前列腺增生患者年龄、前列腺体积以及血清前列腺特异性抗原（prostate-specific antigen，PSA）之间的关系。方法回顾2000～2005年204例确诊为前列腺增生的患者临床资料，采用SPSS10．0软件总结并分析患者年龄、前列腺体积以及血清PSA之间关系。结果204例患者平均年龄为（68．78±6．44）岁，平均体积为（57、33±34．12）ml；平均PSA值（6．90±5．81）μg·L^-1；对患者年龄分组后显示前列腺体积、血清PSA值随患者年龄增长而增加（F=3．05，P=0．03；F=2．74，P=0．044）；血清PSA值随前列腺体积增加而升高（F=11．37，P〈0．001），对患者年龄进行控制后仍然显示PSA值与体积正相关（r=0.31，P〈0.001）。结论前列腺增生患者前列腺体积和血清PSA水平随患者年龄增长而增加，患者血清PSA与前列腺体积正相关。

Aim To discuss relationship between age,prostate volume and prostate specific antigen of patients with benign prostatic hyperplasia （BPH）. Methods 204 cases of inpatients with BPH were retrospected, from 2000 to 2005. Data of patients ＇ age, prostate volume and serum PSA were collected and analyzed with software SPSS 10.0.,Results In all patients,age ranged from 55 to 92 years old （mean 68.78±6.44）, prostate volume ranged from 20 to 193 ml （mean 57.33±34.12 ml）, and value of PSA ranged from 0. 1 to 80. 2 μg·L^-1（ mean 6.90±5.81 μg·L^-1）. The prostate volume and the level of PSA ascend with age （ F = 3.05, P=0.03 ; F=2.74,P=0.044 ）, as well as the level of PSA rise with the volume （F=7.34, P〈0. 001）. There is a positive relationship between the prostate vol- ume and the level of PSA （r=0.31,P〈0.001）. Conclusion Age is a risk factor to BPH, and age and prostate volume both affect the level of serum PSA.