乳腺癌组织中paxillin和c-erbB-2的表达及临床意义

Expression and clinical significance of paxillin and c-erbB-2 in human breast carcinoma

目的:研究paxillin蛋白和c-erbB-2蛋白在乳腺癌组织中的表达,探讨其与乳腺癌患者临床病理因素的关系,以评价乳腺癌的预后。方法:采用免疫组织化学SP法检测53例原发性乳腺癌、10例乳腺纤维腺瘤及10例距癌灶边缘>5cm病理组织学检查正常的乳腺组织中paxillin和c-erbB-2蛋白的表达情况。结果:与正常乳腺组织和乳腺纤维腺瘤相比,乳腺癌中paxillin表达显著降低(P=0.003),而c-erbB-2表达显著增高(P<0.001)。paxillin的表达与患者的年龄、绝经状况、肿瘤细胞的ER和PR表达及肿瘤大小无关,而与病理学分期、组织学分级和淋巴结转移有关;c-erbB-2表达与患者的年龄、绝经状况、肿瘤大小、PR表达和病理学分期无关,而与ER表达、组织学分级和淋巴结转移有关。paxillin和c-erbB-2的表达无相关性。结论:paxillin和c-erbB-2与乳腺癌细胞的恶性转化、侵袭转移有关,检测paxillin和c-erbB-2蛋白表达情况有助于准确评价乳腺癌患者的预后。

Objective： To explore the expression of paxillin and c-erbB-2 in human breast carcinoma and to investigate the relationships of paxillin and c-erbB-2 with clinical and pathological characteristics. Methods： SP immunohistochemistry staining was applied to detect the expression of paxillin and c-erbB-2 in tumor tissues from 53 cases of human primary breast carcinoma, 10 cas- es of breast fibroadenoma and in 10 cases of normal breast tissues. Results Breast carcinoma tis- sues showed lower levels of paxillin （P=0.003） and higher levels of c-erbB-2（.P〈0.00l）than normal and fibroadenoma tissues. The expression of paxillin was relateded with pathological stages, histological grades and lymph node status, but not related with age, menopausal status, ER, PR status and tumor size. The expression of c-erbB-2 was relateded with ER status, histological grades and I lymph node status, but not related with age, menopausal status, PR status,tumor size and pathological stages. There were no correlation between paxillin and c-erbB-2 levels. Conclusion： Paxillin and c-erbB-2 had relations with the malignant transformation, invasion and metastasis of breast carcinoma.