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皮肤病理性瘢痕形成的细胞与分子生物学机制

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摘要 皮肤病理性瘢痕是人体皮肤组织损伤后的一种纤维过度增生性疾病,其发病机制涉及众多因素,是各种细胞及细胞因子相互作用、调控的结果。其组织学特点是大量成纤维细胞(FB)增生,细胞外基质(ECM)过度沉积。肥大细胞(MC)释放细胞因子,刺激ECM合成。Caspase蛋白调控FB细胞的凋亡,参与病理性瘢痕的形成。TGF-β、α-MSH、TNF-α、PDGF、IGF-1、IL-8、bFGF等细胞因子及细胞骨架基因相关蛋白、缝隙连接细胞间通讯在病理性瘢痕的形成过程中均发挥重要作用。
作者 梅新华
机构地区 山东省临沂市人民医院普外科
出处 《中国现代普通外科进展》 CAS 2008年第2期132-135,共4页 Chinese Journal of Current Advances in General Surgery
关键词 瘢痕 细胞凋亡 细胞因子类 细胞骨架基因相关蛋白 缝隙连接细胞间通讯
分类号 R602 [医药卫生—外科学] R649.9 [医药卫生—外科学]
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参考文献31

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中国现代普通外科进展
2008年 第2期

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