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阿片类药物延迟预处理心肌保护作用的研究进展

Advance in research on delayed cardioprotection of opioid analgesic preconditioning
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摘要 与缺血预处理类似，阿片类药物预处理亦可诱发延迟性心肌保护作用，临床应用麻醉性镇痛药如吗啡等可通过激动阿片受体而减轻缺血／再灌注损伤。研究发现，阿片类药物预处理的延迟性心肌保护作用持续时间较长，所以对预防心肌缺血／再灌注损伤更具临床应用价值。此文综述了阿片类药物预处理延迟性心肌保护作用的生理学基础和机制。 Preconditioning with opioid analgesic, drugs,Same as ischemic preconditioning, also induces delayed cardioprotection. Narcotic. analgesics used clinically such as morphine, attenuates ischemia-reperfusion injury via opioid receptors. The delayed cardioprotection of opioid analgesic preconditioning has been demonstrated to last a longer time. Therefore, it is more valuable for prevention of myocardial ischemia-reperfusion injury. This review briefly describes physiological basis and mechanisms of delayed cardioprotection of opioid analgesic preconditioning.
作者 刘鲲鹏 廖旭 薛富善
机构地区 中国医学科学院整形外科医院麻醉科
出处 《国际麻醉学与复苏杂志》 CAS 2008年第2期117-120,共4页 International Journal of Anesthesiology and Resuscitation
关键词 阿片类药物 延迟预处理 心肌保护作用 opioid anesthetics delayed preconditioning cardioprotection
分类号 R96 [医药卫生—药理学]
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参考文献21

  • 1Cohen MV, Baines CP, Downey JM. Ischemic preconditioning: from adenosine receptor to KATP channel. Annu Rev Physiol, 2000,62 : 79- 109.
  • 2Fryer RM ,Wang YG, Hsu AK, et al. Dependence ofδ1 -Opioid receptor induced cardioprotection on a tyrosine kinase-dependent but not a src dependent pathway. JPET,2001,299 :477-482.
  • 3Peart JN, Gross ER, Gross GJ. Effect of exogenous kappa-opioid receptor activation in rat model of myocardial infarction. J Cardiovasc Pharmacol,2004,43:410-415.
  • 4Ventura C, SpUrgeon H, Lakatta EG, et al. Kappa and delta opioid receptor stimulation affects cardiac myocyte function and Ca^2+ relrase from an intracellular pool in myocytes and neurons. Circ Res, 1992,70 : 66-81.
  • 5Yamazaki T,Akiykma T,Mori H. Effects of nociception on cardic nore pinephrine and acetylcholine release evoked by ouabain. Brain Res, 2001, 904:153 -156.
  • 6Zastrow M. Opioid receptor regulation. Neuromoleeular Med,2004,5: 51-58.
  • 7Schultz JJ, Hsu AK, Gross GJ. Ischemic preconditioning is mediated by a peripheral opiopd receptor mechanism in the intact rat heart. J Mol Cell Cardiol, 1997,29 : 1355-1362.
  • 8Patel HH,Hsu A, Moore J, et al. BW373U86, a delta opioid agonist, partially mediates delayed cardioprotection via a free radical mechanism that is independent of opioid receptor stimulation. J Mol Cell Cardiol, 2001,33:1455-1465.
  • 9Gross GJ. Role of opioids in acute and delay preconditioning. J Mol Cell Cardiol,2003 ,35 :709-715.
  • 10Farias M, Jackson KE, Yoshishige D, et al. Cardiac enkephalins interrupt vagal bradycardia via delta2-opioid receptors in sinoatrial node.Am J Physiol Heart Circ Physiol,2003,284.H1693-H1701.

二级参考文献9

  • 1Ylitalo KV, Ala-Rami A, Liimatta EV, et al. Intracellular free calcium and mitochondrial membrane potential in ischemia/reperfusion and preconditioning [J]. J Mol Cell Cardiol, 2000,32(7) : 1223-1238.
  • 2Wang GY, Wu S, Pei JM, et al. Kappa-but not delta-opioid receptors mediate effects of ischemic preconditioning on both infarct and arrhythmia in rats [J]. Am J Physiol Heart Circ Physiol, 2001, 280(1): H384-H391.
  • 3Wu S, Li HY, Wong TM. Cardioprotection of preconditioning by metabolic inhibition in the rat ventricular myocyte. Involvement of kappa-opioid receptor [J]. Circ Res, 1999, 84 (12):1388-1395.
  • 4Vahchanova-Matchouganska A, Ojewole JA. Involvement of opioid delta (delta)- and kappa ( kappa )-receptors in ischemic preconditioning in a rat model of myocardial infarction [J].Methods Find Exp Clin Pharmacol, 2002, 24(3), 139-144.
  • 5Zucchi R, Ronca F, Ronca-Testoni S. Modulation of sarcoplasmic reticulum function: a new strategy in cardioprotectlon? [J].Pharmacol Ther, 2001, 89(1)~ 47-65.
  • 6Liu H, Cala PM, Anderson SE. Ischemic preconditioning: effects on pH, Na and Ca in newborn rabbit hearts during Ischemia/Reperfusion [J]. J Mol Cell Cardiol, 1998, 30(3) : 685-697.
  • 7Przyklenk K, Simkhovich BZ, Bauer B, et al. Cellular mechanisms of infarct size reduction with ischemic preconditioning.Role of calcium? [J]. Ann N Y Acad Sci, 1999, 874:192-210.
  • 8Cross HR, Radda GK, Clarke K. The role of Na^+/K^+ATPase activity during low flow ischemia in preventing myocardial injury:a ^31P,^23Na and ^87Rb NMR spectroscopic study [J]. Magn Reson Med, 1995, 34(5): 673-685.
  • 9Fryer RM, Eells JT, Hsu AK, et al. Ischemic preconditioning in rats: role of mitochondrial K(ATP) channel in preservation of mitochondrial function [J]. Am J Physiol Heart Circ Physiol, 2000, 278(1): H305-H312.

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国际麻醉学与复苏杂志
2008年 第2期

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