芪杞固本汤治疗溃疡性结肠炎的临床疗效及对免疫指标的影响

Curative effect of Qiqi Guben decoction on ulcerative colitis

目的观察芪杞固本汤治疗脾肾气虚型溃疡性结肠炎(UC)的临床疗效。方法将90例患者随机分为芪杞固本汤治疗组50例,柳氮碘胺吡啶(SAPS)对照组40例。芪杞固本汤治疗组予以口服及灌肠,柳氮碘胺吡啶对照组采用口服,疗程60 d。结果芪杞固本汤治疗组临床疗效总有效率为94%,明显优于柳氮碘胺吡啶对照组(P<0.05)。芪杞固本汤治疗组治疗后B淋巴细胞明显下降,外周血总T细胞和Ts明显上升,对照组治疗前、后对比无明显变化(P<0.01)。结论根据中医辨证采用芪杞固本汤口服加灌肠通过调整机体功能和病位用药,使药物直达病所之方法,可改善局部环境,促进局部病变恢复。芪杞固本汤对机体有显著的免疫调节作用,从而促进UC的恢复。

Objective To explore the mechanism of Qiqi Guben（QQGB） decoction treating Ulcerative Colitis（UC）. Methods The 90 patients with UC divided into two groups, in which, 50 patients in treatment group were treated by QQGB with double methods of drinking and clysis, and 40 in control group by tablet Sulfasalazine （SASP）. The treatment course was 60 days. Result The total valid rate in QQGB group was 94%. Which was more effective to that in SASP group （P〈0.05）. After QQGB treatment, the B cell was reduced and Ts cell and total T cell were increased. Conclusion The QQGB decoction is very effective for immunological regulation to promote restoring US.