绝经后女性2型糖尿病患者骨密度与大血管并发症的相关性

Association between bone mineral density and macrovascular complications in postmenopansal women with type 2 diabetes

目的探讨绝经后女性2型糖尿病患者骨密度与大血管并发症的相关性。方法对137例符合1999年世界卫生组织（WHO）糖尿病诊断标准的绝经后女性2型糖尿病住院患者，应用骨密度仪测定骨密度和T值，根据有无大血管并发症分2组，比较骨密度和T值。应用多因素非条件Logistic回归分析骨质疏松与大血管并发症的相关性。结果绝经后女性2型糖尿病合并大血管并发症组的骨密度、T值显著低于不伴有大血管并发症组（P〈0．01～0．05），调整了年龄、血压、血脂、体重指数、糖尿病病程、绝经时间后，经多因素非条件Logistic回归分析显示骨质疏松与大血管并发症仍存在显著的相关性（OR=4．473，95％CI：1．770～11．300）。结论绝经后女性2型糖尿病患者骨密度的降低可能与大血管并发症的发生、发展有关。

Objective To assess the association between bone mineral density and maerovaseular complications in postmenopausal women with type 2 diabetes. Methods To measure bone mineral density and T score of 137 postmenopausal women with type 2 diabetes, we divided these women into two groups according to whether they have maerovaseular complications or not, and analysed the association between osteo~ porosis and maerovascular complications. Results Bone mineral density, T score of patients with maerovascular complications were much lower than those of patients without it. Osteoporosis was related to maerovaseular complications by logistic regression analysis ,regardless of age, pressure, triglyeeride ,body mass index, the duration of diabetes, and menopause time. Conclusion Decrease of bone mineral density in postmenopausal women with type 2 diabetes may be related to the development of maerovascular complications.