β-环糊精衍生的手性氧膦配体在烯烃不对称氢甲酰化反应中的应用

Study on the Asymmetric Hydroformylation Using Chiral Phosphinite Derivative of β Cyclodextrin as Ligand

β－环糊精衍生的手性氧膦配体在烯烃不对称氢甲酰化反应中的应用徐小红周宏英陈静傅宏祥１）（中国科学院兰州化学物理研究所兰州７３００００）关键词β－环糊精手性膦配体不对称氢甲酰化铑催化剂分类号Ｏ６４３．３２糖是一类含有丰富的手性碳原子的天然化合物，一些单...

This paper reports the asymmetric hydroformylation of prochiral substrates using catalysts with the prepared chiral phosphinite ligand derived from β cyclodextrin. The effects of reaction temperature, pressure, solvent, molar ratio of P to Rh have been investigated with this catalyst systems. When the asymmetric hydroformylation of vinyl acetate was carried out at 80℃, 7.0 MPa, P/Rh=3.37 for 24 h, i/n ratio was 100/0 and the e.e. was 27.4%.