150例绝经后妇女骨密度与骨代谢指标的关系

THE RELATIONSHIPS BETWEEN BONE BIOCHEMICAL MARKERS AND BONE MINERAL DENSITY IN 150 POSTMENOPAUSAL WOMEN

[目的]探讨绝经后妇女骨代谢生化指标:血清骨特异性碱性磷酸酶(BALP)和血清抗酒石酸酸性磷酸酶(TRAP)随年龄变化及其与骨密度的关系。[方法]用ELISA测定BALP,光电比色法测定TRAP,超声骨密度仪测定桡骨远端骨密度。[结果]随着年龄增加,BALP、TRAP均增加,SOS值减少。经方差分析BALP、SOS值各年龄组间差异有统计学意义(P﹤0.01),TRAP各年龄组间差异无统计学意义(P﹥0.05)。相关分析,年龄、BALP、TRAP均与SOS值呈负相关(P﹤0.01),相关系数分别为-0.454、-0.346、-0.488。[结论]绝经妇女骨代谢指标与骨密度呈负相关;且BALP是反映绝经后妇女随年龄变化的骨代谢的敏感和特异性指标。

[Objective] To study the relationships of bone-specific alkaline phosphatase （BALP） , tart rate-resistant acid phosphatase （TRAP） with the change of age and bone mineral density （BMD） in postmenopausal women. [Methods] BALP and TRAP were measured using ELISA and photoelectric method respectively; BMD were measured by ultrasound. [Resuits] The measurements of SOS were decreased with the increase of age, and the difference was significant （P 〈 0.01）. The activities of BALP and TRAP increased gradually with the increase of age, and former difference was significant （P 〈 0.01）, latter difference was not significant （P 〉 0.05）. Correlation analysis showed that age, BALP and TRAP were negatively correlated with SOS （r were -0.454, -0.346 and -0.488; P 〈 0.001）. [Conclusions] Levels of bone biomarker negatively correlate with BMD in postmenopausal women. BALP may be the sensitive and relatively specific marker to evaluate bone metabolism in postmenopausal women.